A Simple Non-Invasive Approach Toward Efficient Transdermal Drug Delivery Based on Biodegradable Particulate System

In 2019, a study was conducted to evaluate the optical depth of calcium carbonate particle detection in rat skin and the optical length of follicle filling with these particles. This was done using optical coherent tomography (OCT) in vivo measurements. The optical depth of detection (ODD) was defined as the distance between the skin surface and the deepest visible area of particle localization inside the hair follicle. The optical length of filling (OLF) was the visible follicle length filled with particles. The ODD of calcium carbonate particles in the skin was evaluated on the OCT A-scan as a distance between two peaks: from the skin surface and from the deepest area of the particles localization inside the follicle.