Hair Follicles as a Target Structure for Nanoparticles
TLDR Nanoparticles around 600-700 nm can effectively enter and stay in hair follicles for days, which may help in delivering drugs to specific cells.
The 2015 document explored the use of nanoparticles for targeted drug delivery through hair follicles. It was discovered that nanoparticles with a diameter of around 600-700 nm could efficiently penetrate hair follicles and remain there for days, potentially allowing for the delivery of drugs to specific cells within the follicle. The study also found that the penetration depth of nanoparticles could be influenced by their size and that a triggered release system within the follicles could enable localized drug release at depths of 900-1000 µm. Although nanoparticles alone could not penetrate the follicular barrier, once inside, the released drugs could. This research indicated a promising new method for drug delivery, warranting further investigation. The document did not provide the number of human participants or specify the details of the in vivo and in vitro experiments.
