Study of the Biological Function and Penetration Pathways of the Mouse Epidermal Growth Factor Ethosomal Delivery System

July 2011 in “ Experimental Dermatology ”

Xiao-Jing Xing, Lang Yang, Yi You, Baiyu Zhong, Qiuhe Song, Jun Deng, Fei Hao

mouse epidermal growth factor ethosomal delivery system hair follicles telogen phase anagen phase pilosebaceous unit mEGF ethosomes

TLDR The ethosomal delivery system improves topical drug delivery and promotes hair growth.

The study developed a mouse epidermal growth factor (mEGF) ethosomal delivery system to investigate its penetration pathways and biological functions. The ethosomal system demonstrated enhanced topical drug delivery efficiency, penetrating deeper and faster through the pilosebaceous unit compared to mEGF water solutions and gels. The mEGF ethosomes effectively transitioned hair follicles from the telogen to the anagen phase, indicating their potential as a superior therapeutic option for treating hair and skin disorders. The study concluded that the ethosomal delivery system is beneficial for the topical penetration of biological agents, particularly in advancing hair follicle cycles.

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Research cited in this study

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research A Topical Parathyroid Hormone/Parathyroid Hormone-Related Peptide Receptor Antagonist Stimulates Hair Growth in Mice

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research Effect of Ethosomal Minoxidil on Dermal Delivery and Hair Cycle of C57BL/6 Mice

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Ethosomal minoxidil improves hair growth by penetrating deeper into skin and shortening hair cycle.

research Epidermal Growth Factor as a Biological Switch in Hair Growth Cycle

94 citations , July 2003 in “Journal of biological chemistry/The Journal of biological chemistry”

EGF controls hair growth by regulating hair follicles' growth phases.

research Enhanced Delivery of Drugs Into and Across the Skin by Ethosomal Carriers

182 citations , January 2000 in “Drug Development Research”

Ethosomal carriers improve drug delivery through the skin better than traditional methods.

research Melanogenesis During the Anagen-Catagen-Telogen Transformation of the Murine Hair Cycle

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Hair stops producing melanin as it transitions from the growth phase to the resting phase.

research Melanogenesis Is Coupled to Murine Anagen: New Concepts for the Role of Melanocytes and Regulation of Melanogenesis in Hair Growth

109 citations , July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”

Hair color production is closely linked to the active growth phase of hair in mice and may also influence hair growth itself.

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