Minoxidil-Encapsulated Poly(L-Lactide-Co-Glycolide) Nanoparticles with Hair Follicle Delivery Properties Prepared Using Solvent Evaporation and Sonication

    February 2018 in “ Bio-medical Materials and Engineering ”
    Issei Takeuchi, Yukari Hida, Kimiko Makino
    Studysummary This study demonstrated that minoxidil-encapsulated PLLGA nanoparticles significantly increased minoxidil delivery to hair follicles compared to a minoxidil aqueous solution in mice.
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    Research cited in this study 8

    1. Iontophoresis on Minoxidil Sulphate-Loaded Chitosan Nanoparticles Accelerates Drug Release, Decreasing Their Targeting Effect to Hair Follicles Química Nova · 2016
    2. Delivery and Targeting of Nanoparticles into Hair Follicles Therapeutic Delivery · 2014
    3. Targeted Delivery of a Poorly Water-Soluble Compound to Hair Follicles Using Polymeric Nanoparticle Suspensions International journal of pharmaceutics · 2011
    4. Selective Follicular Targeting by Modification of the Particle Sizes Journal of Controlled Release · 2011
    5. A Multicenter, Randomized, Placebo-Controlled, Double-Blind Clinical Trial of a Novel Formulation of 5% Minoxidil Topical Foam Versus Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2007
    6. Investigation of Differences in Follicular Penetration of Particle- and Nonparticle-Containing Emulsions by Laser Scanning Microscopy Laser Physics · 2006
    7. 40nm, But Not 750 or 1,500nm, Nanoparticles Enter Epidermal CD1a+ Cells After Transcutaneous Application on Human Skin ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2006
    8. Differential Stripping: Determination of the Amount of Topically Applied Substances Penetrated into the Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2005

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    2. Altered Polyamine Profiling in the Hair of Patients with Androgenic Alopecia and Alopecia Areata Journal of Dermatology · 2019
    3. Minoxidil-Encapsulated Poly(L-Lactide-Co-Glycolide) Nanoparticles with Hair Follicle Delivery Properties Prepared Using Solvent Evaporation and Sonication Bio-medical Materials and Engineering · 2018
    4. Advanced Approaches in Alopecia Pharmaceutical and Biological Evaluations · 2017
    5. Alopecia Areata: Overview and Treatment Options Current problems in dermatology · 2015
    6. Treatments for Androgenetic Alopecia and Alopecia Areata Drugs · 2001
    7. Nongenotoxicity of Minoxidil in Murine Hair Follicles as Determined by the Nuclear Aberration Assay Toxicology and Applied Pharmacology · 1988
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