Minoxidil-Encapsulated Poly(L-Lactide-Co-Glycolide) Nanoparticles with Hair Follicle Delivery Properties Prepared Using Solvent Evaporation and Sonication

February 2018 in “ Bio-medical Materials and Engineering ”

Issei Takeuchi, Yukari Hida, Kimiko Makino

minoxidil poly(L-lactide-co-glycolide) PLLGA nanoparticles androgenetic alopecia solvent evaporation sonication stratum corneum hair follicles Rogaine

TLDR Minoxidil inside tiny particles can deliver more drug to hair follicles, potentially improving treatment for hair loss.

In 2018, a study was conducted to prepare minoxidil-encapsulated poly(L-lactide-co-glycolide) (PLLGA) nanoparticles for the treatment of androgenetic alopecia. The nanoparticles were prepared using solvent evaporation and sonication. The study found that these nanoparticles delivered 3.1 times more minoxidil in stratum corneum and 2.5 times more in hair follicles compared to a minoxidil aqueous solution, eight hours after administration. Furthermore, 4.8% of the dose of minoxidil-encapsulated PLLGA nanoparticles were delivered to the hair follicles. The study concluded that nanoparticulation using PLLGA7510 improved drug delivery to hair follicles, making minoxidil-encapsulated PLLGA nanoparticles a potential effective treatment for androgenetic alopecia.

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