Targeted Delivery of a Poorly Water-Soluble Compound to Hair Follicles Using Polymeric Nanoparticle Suspensions

    June 2011 in “ International journal of pharmaceutics ”
    Michael M. Morgen, Guang Wei Lu, Daniel Du … Conglin Fan
    Studysummary This study found that polymeric nanoparticle suspensions can deliver poorly water-soluble drugs to hair follicles in animal models, suggesting a promising method for targeted topical treatments.
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    Research cited in this study 8

    1. Follicular Transport Route: Research Progress and Future Perspectives European journal of pharmaceutics and biopharmaceutics · 2009
    2. Nanoparticle-Based Targeting of Vaccine Compounds to Skin Antigen-Presenting Cells by Hair Follicles and Their Transport in Mice ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2008
    3. The Role of Hair Follicles in the Percutaneous Absorption of Caffeine BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology · 2007
    4. Evaluation of the Permeability of Hair Growing Ingredient Encapsulated PLGA Nanospheres to Hair Follicles and Their Hair Growing Effects Bioorganic & Medicinal Chemistry Letters · 2007
    5. Innovative Liposomes as a Transfollicular Drug Delivery System: Penetration into Porcine Hair Follicles Journal of Investigative Dermatology · 2006
    6. 40nm, But Not 750 or 1,500nm, Nanoparticles Enter Epidermal CD1a+ Cells After Transcutaneous Application on Human Skin ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2006
    7. Podophyllotoxin-Loaded Solid Lipid Nanoparticles for Epidermal Targeting Journal of controlled release · 2005
    8. Transdermal Delivery of Minoxidil with Block Copolymer Nanoparticles Journal of Controlled Release · 2004