Follicle-Targeted Delivery of Betamethasone and Minoxidil Co-Entrapped in Polymeric and Lipid Nanoparticles for Topical Alopecia Areata Treatment

    September 2023 in “ Pharmaceuticals ”
    Breno N. Matos, Ana Luiza Lima, Camila O. Cardoso … Guilherme M. Gelfuso
    Studysummary This study found that nanoparticles containing minoxidil and betamethasone improved drug delivery to hair follicles, with lipidic nanoparticles significantly enhancing minoxidil and betamethasone penetration compared to control, making them a promising option for alopecia areata treatment with reduced side effects.
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    Research cited in this study 18

    1. Nanostructured Lipid Carriers Loaded with Minoxidil and Latanoprost for Targeted Topical Therapy of Alopecia European Journal of Pharmaceutics and Biopharmaceutics · 2022
    2. Follicular-Targeted Delivery of Spironolactone Provided by Polymeric Nanoparticles Colloids and surfaces. B, Biointerfaces · 2021
    3. Topical Treatment for Scarring and Non-Scarring Alopecia: An Overview of the Current Evidence Clinical, Cosmetic and Investigational Dermatology · 2021
    4. Enhancing Permeation of Drug Molecules Across the Skin via Delivery in Nanocarriers: Novel Strategies for Effective Transdermal Applications Frontiers in Bioengineering and Biotechnology · 2021
    5. Latanoprost Loaded in Polymeric Nanocapsules for Effective Topical Treatment of Alopecia AAPS PharmSciTech · 2020
    6. Oral Minoxidil Treatment for Hair Loss: A Review of Efficacy and Safety Journal of The American Academy of Dermatology · 2020
    7. Topical Minoxidil-Loaded Nanotechnology Strategies for Alopecia Cosmetics · 2020
    8. Dutasteride Nanocapsules for Hair Follicle Targeting: Effect of Chitosan-Coating and Physical Stimulus International Journal of Biological Macromolecules · 2020
    9. Minoxidil for Patchy Alopecia Areata: Systematic Review and Meta-Analysis Journal of The European Academy of Dermatology and Venereology · 2019
    10. Treatment of Alopecia Areata: An Australian Expert Consensus Statement Australasian journal of dermatology · 2018
    11. Mesalazine in the Treatment of Extensive Alopecia Areata: A New Therapeutic Option? International Journal of Trichology · 2018
    12. Alopecia Areata: Overview and Insights from January 2018 Journal of The American Academy of Dermatology · 2017
    13. Investigation of the Cutaneous Penetration Behavior of Dexamethasone Loaded to Nano-Sized Lipid Particles by EPR Spectroscopy, and Confocal Raman and Laser Scanning Microscopy European journal of pharmaceutics and biopharmaceutics · 2016
    14. Chitosan Nanoparticles for Targeting and Sustaining Minoxidil Sulphate Delivery to Hair Follicles International Journal of Biological Macromolecules · 2015
    15. Lipid Nanoparticles for Topical and Transdermal Application for Alopecia Treatment: Development, Physicochemical Characterization, and In Vitro Release and Penetration Studies International Journal of Nanomedicine · 2014
    16. Selective Follicular Targeting by Modification of the Particle Sizes Journal of Controlled Release · 2011
    17. Transdermal Delivery of Minoxidil with Block Copolymer Nanoparticles Journal of controlled release · 2004
    18. Transdermal Delivery of Minoxidil with Block Copolymer Nanoparticles Journal of Controlled Release · 2004

    Related research 5

    1. Follicle-Targeted Delivery of Betamethasone and Minoxidil Co-Entrapped in Polymeric and Lipid Nanoparticles for Topical Alopecia Areata Treatment Pharmaceuticals · 2023
    2. Allergic Contact Dermatitis Due to Minoxidil in a Patient With Alopecia Areata Actas Dermo-Sifiliográficas · 2022
    3. Topical Minoxidil for the Treatment of Alopecia Areata PubMed · 2017
    4. Effectivity of Minoxidil as a Treatment for Alopecia Areata DOAJ (DOAJ: Directory of Open Access Journals) · 2013
    5. Comparison of the Efficacy and Safety of Topical 5% Minoxidil Solution Alone and in Combination with 0.05% Betamethasone Dipropionate Cream in the Treatment of Alopecia Areata Annals of King Edward Medical University · 2010