Follicular-Targeted Delivery of Spironolactone Provided by Polymeric Nanoparticles

December 2021 in “ Colloids and surfaces. B, Biointerfaces ”

Ricardo Ferreira‐Nunes, Marcílio Cunha-Filho, Guilherme M. Gelfuso

spironolactone polymeric nanoparticles poly-ε-caprolactone methacrylic acid/methyl methacrylate copolymer alopecia hair follicles PCL EL100

TLDR Nanoparticles can effectively deliver spironolactone to hair follicles for treating alopecia and acne.

This study developed polymeric nanoparticles of different sizes to deliver spironolactone topically for treating acne and alopecia. The nanoparticles, made from poly-ε-caprolactone (PCL) or methacrylic acid/methyl methacrylate copolymer (EL100), were found to be chemically compatible with spironolactone, physically stable, and non-irritating. They effectively stabilized the drug for at least 90 days and controlled its release in aqueous media. Notably, larger nanoparticles (180 nm) significantly enhanced drug delivery to hair follicles compared to smaller ones, making them a promising option for targeted topical therapy.

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