Hormonal Treatment of Acne Vulgaris: An Update

    September 2016 in “ Clinical, Cosmetic and Investigational Dermatology ”
    Mohamed L. Elsaie
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    TLDR Hormonal treatments are effective for severe or persistent acne and should be used with other acne therapies, considering potential side effects.
    The 2016 document details the use of hormonal treatments for acne vulgaris, highlighting that these therapies are suitable for severe, treatment-resistant acne or cases with unpredictable flare-ups, not just for patients with hyperandrogenism. Hormonal therapy, which should be combined with other acne treatments and not used alone, can be effective regardless of androgen levels and typically shows improvement after a 3-month course. The treatments discussed include androgen receptor blockers like spironolactone, oral contraceptives, glucocorticoids, and enzyme inhibitors. Spironolactone is safe for women but has side effects that limit its use in men. Other antiandrogens, oral corticosteroids, combined oral contraceptives, gonadotropin-releasing hormone agonists, and insulin-sensitizing agents are also covered. The document stresses the importance of considering side effects, contraindications, and the need for monitoring with hormonal treatments. Dermatologists should be knowledgeable about these treatments and their appropriate use. No conflicts of interest were reported in the document.
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