A Systematic Review of Spironolactone Nano-Formulations for Topical Treatment of Skin Hyperandrogenic Disorders and Chronic Wounds

    December 2024 in “ Pharmaceutics ”
    Saedah Dereiah, Muhammad Usman Ghori, Barbara R. Conway
    Studysummary This review systematically examined recent advancements in spironolactone-loaded nanocarriers, revealing that lipid and vesicular nanoparticles enhance bioavailability and skin penetration for treating androgen-dependent disorders, but highlighted the need for further clinical studies to optimize their use.
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    Research cited in this study 17

    1. The Efficacy and Safety of Oral and Topical Spironolactone in Androgenetic Alopecia Treatment: A Systematic Review Clinical, Cosmetic and Investigational Dermatology · 2023
    2. Finasteride-Loaded Nano-Lipidic Carriers for Follicular Drug Delivery: Preformulation Screening and Box-Behnken Experimental Design for Optimization of Variables Heliyon · 2022
    3. Niosomal And Ethosomal Gels: A Comparative In Vitro And Ex Vivo Evaluation For Repurposing Of Spironolactone Journal of Drug Delivery Science and Technology · 2022
    4. Trends in the Prescribing Pattern of Spironolactone for Acne and Hidradenitis Suppurativa in Adolescents Journal of The American Academy of Dermatology · 2021
    5. Follicular-Targeted Delivery of Spironolactone Provided by Polymeric Nanoparticles Colloids and surfaces. B, Biointerfaces · 2021
    6. Pharmaceutical and Pharmacological Evaluation of the Effect of Nano-Formulated Spironolactone and Progesterone on Inflammation and Hormonal Levels for Managing Hirsutism Experimentally Induced in Rats AAPS PharmSciTech · 2021
    7. Polymeric Micelle Mediated Follicular Delivery of Spironolactone: Targeting the Mineralocorticoid Receptor to Prevent Glucocorticoid-Induced Activation and Delayed Cutaneous Wound Healing International Journal of Pharmaceutics · 2021
    8. Topical Minoxidil-Loaded Nanotechnology Strategies for Alopecia Cosmetics · 2020
    9. Cyproterone Acetate-Loaded Nanostructured Lipid Carriers: Effect of Particle Size on Skin Penetration and Follicular Targeting Pharmaceutical development and technology · 2019
    10. Androgens in Women: Hormone-Modulating Therapies for Androgen-Mediated Cutaneous Disorders Journal of The American Academy of Dermatology · 2018
    11. Development and Optimization of Spironolactone Nanoparticles for Enhanced Dissolution Rates and Stability Aaps Pharmscitech · 2016
    12. Ceramide Synthase 4 Regulates Stem Cell Homeostasis And Hair Follicle Cycling Journal of Investigative Dermatology · 2015
    13. Self-Assembled Polymeric Nanocarriers for the Targeted Delivery of Retinoic Acid to the Hair Follicle Nanoscale · 2015
    14. Follicular Delivery of Spironolactone via Nanostructured Lipid Carriers for Management of Alopecia International Journal of Nanomedicine · 2014
    15. Spironolactone May Reduce the Risk of Incident Rosacea Journal of Investigative Dermatology · 2013
    16. Targeted Skin Overexpression of the Mineralocorticoid Receptor in Mice Causes Epidermal Atrophy, Premature Skin Barrier Formation, Eye Abnormalities, and Alopecia American Journal of Pathology · 2007
    17. Enhanced Delivery of Drugs Into and Across the Skin by Ethosomal Carriers Drug Development Research · 2000