Cyproterone Acetate-Loaded Nanostructured Lipid Carriers: Effect of Particle Size on Skin Penetration and Follicular Targeting

March 2019 in “ Pharmaceutical development and technology ”

Parisa Ghasemiyeh, Amir Azadi, Saeid Daneshamouz, Reza Heidari, Negar Azarpira, Soliman Mohammadi-Samani

cyproterone acetate nanostructured lipid carriers NLCs skin penetration follicular targeting androgenic alopecia

Studysummary The study found that cyproterone acetate-loaded nanostructured lipid carriers, particularly those with a 300 nm diameter, improved skin penetration and targeted hair follicles more effectively than free cyproterone acetate. Our plain-language summary of this paper — not a Tressless recommendation.

The study investigated the effect of particle size on the skin penetration and follicular targeting of cyproterone acetate-loaded nanostructured lipid carriers (NLCs). The researchers found that smaller particle sizes significantly enhanced skin penetration and follicular targeting compared to larger particles. This suggests that optimizing the particle size of NLCs could improve the delivery and efficacy of cyproterone acetate for treating conditions like androgenic alopecia. The findings highlighted the potential of NLCs as a promising delivery system for topical treatments.

View this study on tandfonline.com →

Discuss this study in the Community →

Research cited in this study

13 / 13 results

research Development and Optimization of Spironolactone Nanoparticles for Enhanced Dissolution Rates and Stability

38 citations , November 2016 in “Aaps Pharmscitech”

This study found that the nanostructured lipid carrier formulation with a 70:30 solid to liquid lipid ratio significantly increased the dissolution rate, entrapment efficiency, and stability of spironolactone compared to its raw form.

research The Effect of Particle Size on the Deposition of Solid Lipid Nanoparticles in Different Skin Layers: A Histological Study

128 citations , March 2016 in “Advanced Pharmaceutical Bulletin”

This study found that sub-100 nm size solid lipid nanoparticles showed the most effective skin penetration and depth, mainly via hair follicles, in rat skin.

research Roxithromycin-Loaded Lipid Nanoparticles for Follicular Targeting

35 citations , October 2015 in “International Journal of Pharmaceutics”

Tiny particles carrying roxithromycin can effectively target and deliver the drug to hair follicles without irritation.

research Applications and Limitations of Lipid Nanoparticles in Dermal and Transdermal Drug Delivery via the Follicular Route

95 citations , July 2015 in “European journal of pharmaceutics and biopharmaceutics”

This review discusses the application of lipid nanoparticles for enhancing drug delivery through hair follicles and reports no new clinical results, emphasizing the potential role of sebum-like lipids in this context.

research Improved Poly (D,L-Lactide) Nanoparticles-Based Formulation for Hair Follicle Targeting

19 citations , January 2015 in “International Journal of Cosmetic Science”

This study reports that optimized PLA nanoparticles can effectively target hair follicles to deliver both lipophilic and hydrophilic compounds, suggesting potential applications in hair cosmetics and treatments.

Comparison of Rheological Properties, Follicular Penetration, Drug Release, and Permeation Behavior of a Novel Topical Drug Delivery System and a Conventional Cream

research Comparison of Rheological Properties, Follicular Penetration, Drug Release, and Permeation Behavior of a Novel Topical Drug Delivery System and a Conventional Cream

34 citations , October 2014 in “European journal of pharmaceutics and biopharmaceutics”

This study found that adapalene-loaded solid lipid microparticles may enhance targeted drug delivery into sebum due to their similarity to sebum components, although both this formulation and a standard cream showed equivalent follicular penetration.

research Topical Formulations Containing Finasteride: In Vitro Permeation/Penetration Study and In Vivo Pharmacokinetics in Hairless Rat

23 citations , June 2014 in “Journal of Pharmaceutical Sciences”

This study found that the HPCH-based formulation P-08–016 may facilitate finasteride deposition in the dermis, potentially offering an alternative to systemic therapy by minimizing systemic absorption.

Topical Formulations Containing Finasteride: Determination of Finasteride Penetration into Hair Follicles Using the Differential Stripping Technique

research Topical Formulations Containing Finasteride: Determination of Finasteride Penetration into Hair Follicles Using the Differential Stripping Technique

14 citations , June 2014 in “Journal of Pharmaceutical Sciences”

This study validated the differential stripping technique on hairless rat skin and found that the P-08–016 formulation delivered more finasteride to the epidermis and appendages compared to P-10–008.

research Solid Lipid Nanoparticles: Method, Characterization, and Applications

191 citations , October 2012 in “International Current Pharmaceutical Journal”

This review discusses the potential uses, benefits, and challenges of solid lipid nanoparticles in drug delivery systems but presents no new experimental findings.

research Hair Follicle Targeting with Nanoparticles

5 citations , September 2012 in “Springer eBooks”

Nanoparticles can be used to deliver drugs to hair follicles, potentially improving treatments for conditions like acne and alopecia, and could also be used for vaccine delivery and gene therapy.

research Selective Follicular Targeting by Modification of the Particle Sizes

263 citations , February 2011 in “Journal of Controlled Release”

This study found that medium-sized particles (643 and 646 nm) penetrated deeper into porcine hair follicles in vitro than smaller or larger particles, suggesting size-selective targeting within follicular sites.

research Determination of the Cuticle Thickness of Human and Porcine Hairs and Their Potential Influence on the Penetration of Nanoparticles into the Hair Follicles

95 citations , January 2009 in “Journal of Biomedical Optics”

This study observed that particles sized 300-600 nm penetrate hair follicles more efficiently, likely due to alignment with the thickness of the human hair cuticula.

research Penetration Profile of Microspheres in Follicular Targeting of Terminal Hair Follicles

316 citations , June 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that using a standardized protocol with microspheres of approximately 1.5 micrometers enhances penetration into hair follicles, particularly when skin is treated with cyanoacrylate skin surface stripping.