Cyproterone Acetate-Loaded Nanostructured Lipid Carriers: Effect of Particle Size on Skin Penetration and Follicular Targeting

    March 2019 in “ Pharmaceutical development and technology ”
    Parisa Ghasemiyeh, Amir Azadi, Saeid Daneshamouz, Reza Heidari, Negar Azarpira, Soliman Mohammadi-Samani
    TLDR Smaller particles of the drug carrier penetrated skin better, with 300 nm size being best for targeting hair follicles.
    The study investigated the effect of particle size on the skin penetration and follicular targeting of cyproterone acetate-loaded nanostructured lipid carriers (NLCs). The researchers found that smaller particle sizes significantly enhanced skin penetration and follicular targeting compared to larger particles. This suggests that optimizing the particle size of NLCs could improve the delivery and efficacy of cyproterone acetate for treating conditions like androgenic alopecia. The findings highlighted the potential of NLCs as a promising delivery system for topical treatments.
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