Topical Formulations Containing Finasteride: Determination of Finasteride Penetration into Hair Follicles Using the Differential Stripping Technique

    June 2014 in “ Journal of Pharmaceutical Sciences ”
    Silvia Tampucci, Susi Burgalassi, Patrizia Chetoni … Daniela Monti
    Studysummary This study validated the differential stripping technique on hairless rat skin and found that the P-08–016 formulation delivered more finasteride to the epidermis and appendages compared to P-10–008.
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    Research cited in this study 19

    1. Topical Formulations Containing Finasteride: In Vitro Permeation/Penetration Study and In Vivo Pharmacokinetics in Hairless Rat Journal of Pharmaceutical Sciences · 2014
    2. Squarticles as a Lipid Nanocarrier for Delivering Diphencyprone and Minoxidil to Hair Follicles and Human Dermal Papilla Cells Aaps Journal · 2013
    3. Drug Delivery to Hair Follicles Expert opinion on drug delivery · 2013
    4. Squalene-Containing Nanostructured Lipid Carriers Promote Percutaneous Absorption and Hair Follicle Targeting of Diphencyprone for Treating Alopecia Areata Pharmaceutical Research · 2012
    5. Methods for Quantifying Intrafollicular Drug Delivery: A Critical Appraisal Expert Opinion on Drug Delivery · 2010
    6. Targeting to the Hair Follicles: Current Status and Potential Journal of dermatological science · 2010
    7. Relative Uptake of Minoxidil Into Appendages and Stratum Corneum and Permeation Through Human Skin In Vitro Journal of Pharmaceutical Sciences · 2009
    8. Comparison of Two In Vitro Models for the Analysis of Follicular Penetration and Its Prevention by Barrier Emulsions European journal of pharmaceutics and biopharmaceutics · 2009
    9. Follicular Transport Route: Research Progress and Future Perspectives European journal of pharmaceutics and biopharmaceutics · 2009
    10. Comparing the Therapeutic Effects of Finasteride Gel and Tablet in Treatment of Androgenetic Alopecia Indian Journal of Dermatology, Venereology and Leprology · 2009
    11. The Role of Hair Follicles in the Percutaneous Absorption of Caffeine BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology · 2007
    12. Diffusion Properties of Model Compounds in Artificial Sebum International journal of pharmaceutics · 2007
    13. Enhancement of Follicular Delivery of Finasteride by Liposomes and Niosomes International Journal of Pharmaceutics · 2006
    14. Transfollicular Drug Delivery: Is It a Reality? International journal of pharmaceutics · 2005
    15. Differential Stripping: Determination of the Amount of Topically Applied Substances Penetrated into the Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2005
    16. Variations of Hair Follicle Size and Distribution in Different Body Sites Journal of Investigative Dermatology · 2004
    17. Penetration and Distribution of Three Lipophilic Probes in Human Skin Focusing on the Hair Follicle Journal of controlled release · 2002
    18. Importance of Sebaceous Glands in Cutaneous Penetration of an Antiandrogen: Target Effect of Liposomes Journal of Pharmaceutical Sciences · 1997
    19. Evaluation of the Hairless Rat as a Model for In Vivo Percutaneous Absorption Journal of Pharmaceutical Sciences · 1997

    Related research 3

    1. Topical Formulations Containing Finasteride: Determination of Finasteride Penetration into Hair Follicles Using the Differential Stripping Technique Journal of Pharmaceutical Sciences · 2014
    2. Human Hair Follicle: Reservoir Function and Selective Targeting British Journal of Dermatology · 2011
    3. Differential Stripping: Determination of the Amount of Topically Applied Substances Penetrated into the Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2005