Topical Formulations Containing Finasteride: Determination of Finasteride Penetration into Hair Follicles Using the Differential Stripping Technique

June 2014 in “ Journal of Pharmaceutical Sciences ”

Silvia Tampucci, Susi Burgalassi, Patrizia Chetoni, Carla Lenzi, Andrea Pirone, Federico Mailland, Maurizio Caserini, Daniela Monti

finasteride topical formulations differential stripping technique hair follicles epidermis male pattern baldness systemic therapy Propecia

Studysummary This study validated the differential stripping technique on hairless rat skin and found that the P-08–016 formulation delivered more finasteride to the epidermis and appendages compared to P-10–008.

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The study aimed to determine the effectiveness of two topical formulations containing finasteride for hair loss treatment. The differential stripping technique was used to measure the amount of finasteride that penetrated into hair follicles. The results showed that the formulation P-08-016 was more effective in retaining finasteride in the epidermis and hair follicles than P-10-008. The study suggests that selective finasteride targeting to hair follicles could represent a valid alternative to systemic therapy for the treatment of male pattern baldness.

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