Squalene-Containing Nanostructured Lipid Carriers Promote Percutaneous Absorption and Hair Follicle Targeting of Diphencyprone for Treating Alopecia Areata

    October 2012 in “ Pharmaceutical Research ”
    Yin-Ku Lin, Saleh A. Al‐Suwayeh, Yann‐Lii Leu, Fengming Shen, Jia‐You Fang
    Image of study
    TLDR Squalene-based carriers improve delivery of a treatment to hair follicles for alopecia areata.
    In the 2012 study, researchers explored the effectiveness of squalene-containing nanostructured lipid carriers (NLCs) in enhancing the delivery of Diphencyprone (DPCP) to hair follicles for the treatment of alopecia areata. The NLCs were formulated in different compositions and assessed for their size, zeta potential, and DPCP encapsulation efficiency. The study found that NLCs, particularly those with added soybean phosphatidylcholine (SPC), significantly improved the skin retention of DPCP, with the SPC-enhanced formulation achieving 275 µg/g skin retention and showing greater follicular deposition. Cationic NLCs were effectively internalized by keratinocytes, and in vivo studies confirmed higher skin retention of DPCP with SPC-enriched NLCs compared to free DPCP. Confocal imaging demonstrated the localization of NLCs in hair follicles, indicating that specific NLC formulations could be promising for improving DPCP absorption in alopecia areata treatment.
    Discuss this study in the Community →

    Research cited in this study

    10 / 10 results

    Related Community Posts Join

    6 / 9 results

      community 37/m, 9 months progress, topical 5%min and 6%Fin

      in Progress Pictures  175 upvotes 2 months ago
      A 37-year-old man experienced significant hair regrowth over nine months using a topical solution of 5% Minoxidil and 0.3% Finasteride. He reported no side effects and noted the treatment's effectiveness despite initial dosage confusion.

      community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

      in Research/Science  63 upvotes 1 year ago
      Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

      community Why do so many people trash on finasteride?

      in Chat  247 upvotes 3 weeks ago
      Finasteride is effective for hair regrowth, especially on the crown, but can cause side effects like reduced libido and erectile dysfunction in some users. Opinions are mixed, with some reporting positive results without side effects and others experiencing significant issues.
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 6 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Min and retinol? Anyone tried it?

      in Research/Science  5 upvotes 1 year ago
      The conversation discusses using minoxidil with retinol for hair loss treatment. Users share their experiences and opinions on the effectiveness of this combination.

    Related Research

    1 / 1 results