Podophyllotoxin-Loaded Solid Lipid Nanoparticles for Epidermal Targeting

December 2005 in “ Journal of controlled release ”

Huabing Chen, Xueling Chang, Danrong Du, Wei Liu, Jie Liu, Ting Weng, Yajiang Yang, Huibi Xu, Xiangliang Yang

podophyllotoxin solid lipid nanoparticles epidermal targeting high pressure homogenization poloxamer 188 soybean lecithin polysorbate 80 stratum corneum hair follicle POD SLN P-SLN T-SLN

Studysummary This study found that POD-loaded solid lipid nanoparticles using 0.5% poloxamer 188 and 1.5% soybean lecithin (P-SLN) improved epidermal targeting and POD accumulation in porcine skin compared to traditional tincture.

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