Podophyllotoxin-Loaded Solid Lipid Nanoparticles for Epidermal Targeting

    January 2006 in “ Journal of controlled release ”
    Huabing Chen, Xueling Chang, Danrong Du, Wei Liu, Jie Liu, Ting Weng, Yajiang Yang, Huibi Xu, Xiangliang Yang
    TLDR P-SLN nanoparticles effectively deliver podophyllotoxin to the skin.
    The study developed podophyllotoxin-loaded solid lipid nanoparticles (P-SLN) for topical delivery to treat genital warts, aiming to enhance epidermal targeting and reduce systemic absorption and skin irritation. The P-SLN were prepared using high pressure homogenization and showed a significant increase in podophyllotoxin accumulation in porcine skin, 3.48 times higher than a 0.15% tincture. P-SLN demonstrated strong localization within the epidermis, suggesting effective epidermal targeting, while T-SLN did not show similar results. This approach could potentially improve the efficacy and safety of podophyllotoxin for treating genital warts.
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