TLDR Diphencyprone increases Bcl-2 protein in patients with hair regrowth from alopecia areata.
The study investigated the effects of diphencyprone (DPCP) on the expression of Bcl-2 protein in patients with Alopecia areata. The results indicated that DPCP treatment led to a significant increase in Bcl-2 protein expression in the affected hair follicles. This suggests that DPCP may promote hair regrowth by enhancing the survival of hair follicle cells through the upregulation of Bcl-2, a protein known for its role in inhibiting apoptosis (cell death). The study provided evidence supporting the potential therapeutic use of DPCP in managing Alopecia areata.
286 citations
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August 2007 in “Journal of Clinical Investigation” Alopecia areata is an autoimmune disease where T cells attack hair follicles.
27 citations
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May 2007 in “Archives of dermatological research” Diphencyprone treatment increases CD8 lymphocytes in the scalp, which is associated with hair regrowth in alopecia areata patients.
30 citations
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April 2007 in “Journal of Leukocyte Biology” Blocking CD44 can reduce leukocyte migration in autoimmune skin diseases.
58 citations
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May 2004 in “British Journal of Dermatology” Diphenylcyclopropenone treatment helps hair growth in alopecia areata by promoting blood vessel growth and cell survival.
47 citations
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April 2000 in “The American journal of pathology” Bcl-2 overexpression protects against UVB damage but worsens hair loss from chemotherapy.
54 citations
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December 1999 in “Journal of Investigative Dermatology Symposium Proceedings”
October 2023 in “Acta dermato-venereologica (Print)” People with severe hair loss have lower zinc levels in their blood.
