The Hair Loss Encyclopedia

Effects of Diphencyprone on Expression of Bcl-2 Protein in Patients with Alopecia Areata

January 2010 in “ Immunopharmacology and immunotoxicology ”

Hamidreza Pazoki‐Toroudi, Marjan Ajami, Shahab Babakoohi, Pejvak Khaki, Rouhollah Habibey, Maryam Akhiani, Sk. Sarif Hassan, Alireza Firooz

diphencyprone Bcl-2 protein Alopecia areata hair follicles apoptosis DPCP

TLDR Diphencyprone increases Bcl-2 protein in patients with hair regrowth from alopecia areata.

The study investigated the effects of diphencyprone (DPCP) on the expression of Bcl-2 protein in patients with Alopecia areata. The results indicated that DPCP treatment led to a significant increase in Bcl-2 protein expression in the affected hair follicles. This suggests that DPCP may promote hair regrowth by enhancing the survival of hair follicle cells through the upregulation of Bcl-2, a protein known for its role in inhibiting apoptosis (cell death). The study provided evidence supporting the potential therapeutic use of DPCP in managing Alopecia areata.

View this study on tandfonline.com →

Discuss this study in the Community →

Research cited in this study

3 / 3 results

research Lymphocytes, Neuropeptides, And Genes Involved In Alopecia Areata

286 citations, August 2007 in “Journal of Clinical Investigation”

Alopecia areata is an autoimmune disease where T cells attack hair follicles.

Changes in Distribution Pattern of CD8 Lymphocytes in the Scalp in Alopecia Areata During Treatment With Diphenylcyclopropenone

research Changes in Distribution Pattern of CD8 Lymphocytes in the Scalp in Alopecia Areata During Treatment With Diphenylcyclopropenone

27 citations, May 2007 in “Archives of dermatological research”

Diphencyprone treatment increases CD8 lymphocytes in the scalp, which is associated with hair regrowth in alopecia areata patients.

Overexpression of Bcl-2 Protects from Ultraviolet B-Induced Apoptosis but Promotes Hair Follicle Regression and Chemotherapy-Induced Alopecia

research Overexpression of Bcl-2 Protects from Ultraviolet B-Induced Apoptosis but Promotes Hair Follicle Regression and Chemotherapy-Induced Alopecia

47 citations, April 2000 in “The American journal of pathology”

Bcl-2 overexpression protects against UVB damage but worsens hair loss from chemotherapy.

Related Community Posts Join

0 / 0 results

— no results

Related Research

1 / 1 results

Serum Zinc Concentration in Patients With Alopecia Areata

research Serum Zinc Concentration in Patients With Alopecia Areata

October 2023 in “Acta dermato-venereologica (Print)”

People with severe hair loss have lower zinc levels in their blood.