Potential of Nanoparticles as Permeation Enhancers and Targeted Delivery Options for Skin: Advantages and Disadvantages
August 2020
in “
Drug Design Development and Therapy
”
nanoparticles nanoemulsions solid lipid nanoparticles nanostructured lipid carriers liposomes niosomes nanocrystals drug stability controlled release drug deposition targeted delivery hair follicles acne alopecia hirsutism skin barrier disruption surfactants formulation complexity toxicity systemic absorption hair loss excessive hair growth
TLDR Nanoparticles can improve skin drug delivery but have challenges like toxicity and stability that need more research.
The document from August 1, 2020, reviews the potential of nanoparticles as permeation enhancers and targeted delivery systems for skin treatments, discussing various types such as nanoemulsions, solid lipid nanoparticles, nanostructured lipid carriers, liposomes, niosomes, and nanocrystals. It outlines the advantages of nanoparticles, including improved drug stability, controlled release, higher drug deposition, and targeted delivery to skin organelles like hair follicles, which is beneficial for conditions like acne, alopecia, and hirsutism. However, it also addresses the disadvantages, such as potential skin barrier disruption, the need for surfactants, and formulation complexity. The document concludes that while nanoparticles offer many benefits for skin drug delivery, challenges such as toxicity, stability, and systemic absorption need to be addressed, and further research is necessary to optimize their dermatological applications.
