Novel Delivery Strategy: Finasteride-Loaded Solid Lipid Nanoparticles for Improved Androgenetic Alopecia Therapy

    January 2025 in “ RSC Advances ”
    Harekrishna Roy, Balaji Maddiboyina, Bhabani Shankar Nayak, Raghvendra A. Bohara
    Studysummary This study reported that a new formulation of finasteride solid lipid nanoparticles, combined with LPC and NTC, enhanced hair growth in mice without visible skin reactions, suggesting it could effectively manage androgenetic alopecia.
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    Research cited in this study 16

    1. Topical Minoxidil Reported Hair Discoloration: A Cross-Sectional Study Dermatology Reports · 2023
    2. Development and Evaluation of Finasteride Niosomes Targeting Hair Follicles for Androgenic Alopecia Management Journal of Drug Delivery Science and Technology · 2023
    3. Effect of cyclosporine A - tempol topical gel for the treatment of alopecia and anti-inflammatory disorders International Journal of Pharmaceutics · 2023
    4. Compliance to Topical Minoxidil and Reasons for Discontinuation Among Patients With Androgenetic Alopecia Dermatology and therapy · 2023
    5. Bioengineered Polyester Nanoparticles for the Synergistic Treatment of Androgenic Alopecia via the Suppression of 5α-Reductase and Knockdown of Androgen Receptor Frontiers in Bioengineering and Biotechnology · 2022
    6. Global Online Interest in Finasteride Sexual Side Effects International Journal of Impotence Research · 2022
    7. Androgen Receptor-Mediated Paracrine Signaling Induces Regression of Blood Vessels in the Dermal Papilla in Androgenetic Alopecia Journal of Investigative Dermatology · 2022
    8. Systematic Review and Meta-Analysis of the Association Between Metabolic Syndrome and Androgenetic Alopecia Acta dermato-venereologica · 2021
    9. Finasteride Interferes with Prostaglandin-Induced CatSper Signalling in Human Sperm Reproduction · 2021
    10. 5-Alpha Reductase Inhibitors in Androgenetic Alopecia: Shifting Paradigms, Current Concepts, Comparative Efficacy, and Safety Dermatologic Therapy · 2020
    11. Fibrosing Alopecia in a Pattern Distribution Journal of The American Academy of Dermatology · 2020
    12. Post-Finasteride Syndrome: A Surmountable Challenge for Clinicians Fertility and Sterility · 2020
    13. Finasteride Nano-Transferosomal Gel Formula for Management of Androgenetic Alopecia: Ex Vivo Investigational Approach Drug Design Development and Therapy · 2018
    14. Androgen Receptor Gene Polymorphisms and Risk for Androgenetic Alopecia: A Meta-Analysis Clinical and Experimental Dermatology · 2011
    15. A Mouse Model of Androgenetic Alopecia Endocrinology · 2010
    16. Androgen Receptor Polymorphisms (CAG Repeat Lengths) in Androgenetic Alopecia, Hirsutism, and Acne Journal of Cutaneous Medicine and Surgery · 1998

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