Finasteride Interferes with Prostaglandin-Induced CatSper Signalling in Human Sperm
March 2021
in “
Reproduction
”
New to Finasteride? There is a guide in the encyclopedia. Read the guide → Studysummary This study found that finasteride may affect Ca 2+ signalling in human sperm by interacting with the PGE 1 -binding site, but its impact on fertilization requires further investigation.
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The study investigated the effects of finasteride on Ca2+ signaling in human sperm, particularly through the CatSper channel. Finasteride caused a minor transient rise in intracellular Ca2+ concentration and inhibited PGE1-induced Ca2+ signals but did not affect progesterone-induced signaling, acrosome reaction, or sperm viability. It also reduced PGE1-induced sperm penetration into a viscous medium at higher concentrations than typically found in blood and seminal fluids. The findings suggested that finasteride might affect Ca2+ signaling in sperm by interacting with the PGE1-binding site, indicating potential implications for male fertility and the need for further research to understand its impact on fertilization and prostaglandin signaling in other parts of the body.
