Finasteride Interferes with Prostaglandin-Induced CatSper Signalling in Human Sperm

    March 2021 in “ Reproduction ”
    Michala Rosa Birch, Steen Dissing, Niels E. Skakkebæk, Anders Rehfeld
    TLDR Finasteride may affect male fertility by interfering with specific sperm signaling.
    The study investigated the effects of finasteride on Ca2+ signaling in human sperm, particularly through the CatSper channel. Finasteride caused a minor transient rise in intracellular Ca2+ concentration and inhibited PGE1-induced Ca2+ signals but did not affect progesterone-induced signaling, acrosome reaction, or sperm viability. It also reduced PGE1-induced sperm penetration into a viscous medium at higher concentrations than typically found in blood and seminal fluids. The findings suggested that finasteride might affect Ca2+ signaling in sperm by interacting with the PGE1-binding site, indicating potential implications for male fertility and the need for further research to understand its impact on fertilization and prostaglandin signaling in other parts of the body.
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