Finasteride Interferes with Prostaglandin-Induced CatSper Signalling in Human Sperm

    March 2021 in “ Reproduction ”
    Michala Rosa Birch, Steen Dissing, Niels E. Skakkebæk, Anders Rehfeld
    Studysummary This study found that finasteride may affect Ca 2+ signalling in human sperm by interacting with the PGE 1 -binding site, but its impact on fertilization requires further investigation.
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    Research cited in this study 4

    1. Post-Finasteride Syndrome: Risks and Side Effects of Finasteride for Androgenetic Alopecia Anais Brasileiros De Dermatologia · 2020
    2. Effect of 1-Mg Dose of Finasteride on Spermatogenesis and Pregnancy International Journal of Andrology · 2010
    3. The Effect of 5α-Reductase Inhibition with Dutasteride and Finasteride on Semen Parameters and Serum Hormones in Healthy Men The Journal of Clinical Endocrinology and Metabolism · 2007
    4. Chronic Treatment with Finasteride Daily Does Not Affect Spermatogenesis or Semen Production in Young Men The Journal of Urology · 1999