Physiology of Testicular Function

    January 2023 in “ Andrology
    Joachim Wistuba, Nina Neuhaus, Eberhard Nieschlag
    TLDR The testes produce sperm and hormones essential for male development.
    The testes have two main functions: producing sperm and acting as an endocrine gland to produce androgens, which are essential for male development. They are structured into seminiferous tubules for sperm production and an interstitial area with Leydig cells for androgen synthesis. Sertoli cells form the blood-testis barrier, protecting germ cells and supporting stem cells. Testicular function is regulated by the hypothalamic-pituitary-gonadal axis, with hormones like LH and FSH promoting testosterone production and spermatogenesis. Testosterone is crucial for male development, influencing various bodily functions. Disorders in testicular function, due to genetic or disease-related causes, can result in infertility and hypogonadism.
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