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GlossarySertoli cells

specialized cells in testes supporting and nurturing sperm development

Sertoli cells are specialized cells found in the testes that play a crucial role in supporting and nurturing developing sperm cells. They create a protective environment, provide nutrients, and help regulate the process of spermatogenesis, which is the production of sperm. These cells also form the blood-testis barrier, which protects germ cells from harmful substances and immune system attacks.

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research Intratesticular Control of Steroidogenesis

79 citations, December 1990 in “Clinical endocrinology”

The testes control steroid production through complex interactions involving various cells and signaling molecules.

research Reproductive System, Male: Biology of Spermatogenesis and Toxicology

2 citations, January 2014 in “Elsevier eBooks”

The document explains how sperm cells are produced, the role of testosterone in this process, and how toxins can reduce sperm count and fertility.

research Restoration of Spermatogenesis and Male Fertility Using an Androgen Receptor Transgene

15 citations, March 2015 in “PloS one”

Scientists restored fertility in male mice lacking a key fertility gene by using a modified gene.

research Novel Androgen Receptor Gene Variant Containing a Premature Termination Codon in a Patient with Androgen Insensitivity Syndrome

1 citations, August 2019 in “Journal of pediatric & adolescent gynecology”

A new genetic change causing early stop in the androgen receptor gene was found in a patient with androgen insensitivity syndrome.

research Finasteride and Male Fertility

1 citations, May 2011 in “Journal of Human Reproductive Sciences”

Finasteride may decrease semen quality but not harm sperm production, and stopping the drug can improve semen quality; hyperprolactinemia can cause infertility but is treatable with medication.

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