Development and Evaluation of Finasteride Niosomes Targeting Hair Follicles for Androgenic Alopecia Management

    July 2023 in “ Journal of Drug Delivery Science and Technology ”
    Fei Liu, Feng Guo, Desheng Liang, Fulin Li, Yating Cao, Mengqi Chen, Jianjun Xu, Xinliang Liu, Haijun Zhong
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    TLDR Finasteride niosomes were developed and found to be effective in treating hair loss, with better results than commercial minoxidil, and could be a promising topical treatment for hair loss.
    The study developed and evaluated finasteride niosomes (FIN-NIS) as a dermal delivery system for the treatment of androgenetic alopecia (AGA), a common hair loss disorder. Finasteride, an oral drug that inhibits the conversion of testosterone to dihydrotestosterone, has been used to treat AGA, but long-term oral administration can lead to serious systemic side effects. The researchers found that FIN-NIS enhanced finasteride permeation and retention, particularly increasing drug concentration in hair follicles. The therapeutic efficacy of FIN-NIS on testosterone-induced AGA mice was higher than that of commercial minoxidil in terms of hair regrowth and anagen restoration. Therefore, FIN-NIS could be a promising dermal topical delivery system for the treatment of AGA.
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