Development and Evaluation of Finasteride Niosomes Targeting Hair Follicles for Androgenic Alopecia Management

    July 2023 in “ Journal of Drug Delivery Science and Technology ”
    Fei Liu, Feng Guo, Desheng Liang, Fulin Li, Yating Cao, Mengqi Chen, Jianjun Xu, Xinliang Liu, Haijun Zhong
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    TLDR Finasteride niosomes were developed and found to be effective in treating hair loss, with better results than commercial minoxidil, and could be a promising topical treatment for hair loss.
    The study developed and evaluated finasteride niosomes (FIN-NIS) as a dermal delivery system for the treatment of androgenetic alopecia (AGA), a common hair loss disorder. Finasteride, an oral drug that inhibits the conversion of testosterone to dihydrotestosterone, has been used to treat AGA, but long-term oral administration can lead to serious systemic side effects. The researchers found that FIN-NIS enhanced finasteride permeation and retention, particularly increasing drug concentration in hair follicles. The therapeutic efficacy of FIN-NIS on testosterone-induced AGA mice was higher than that of commercial minoxidil in terms of hair regrowth and anagen restoration. Therefore, FIN-NIS could be a promising dermal topical delivery system for the treatment of AGA.
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      in Finasteride  99 upvotes 1 week ago
      A 23-year-old male plans to temporarily stop finasteride to donate plasma for financial reasons and seeks alternative hair loss treatments like minoxidil, ketoconazole, or RU58841 during this period. He is open to suggestions to prevent further hair loss until he can resume finasteride.

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      in Finasteride  98 upvotes 1 week ago
      Topical finasteride is considered safer for the liver than oral finasteride due to less systemic absorption, but regular liver function tests are advised. The user is concerned about liver health due to a history of NAFLD and is exploring topical finasteride as a safer alternative.

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      in Finasteride  90 upvotes 2 weeks ago
      After 8 months of using oral Minoxidil 5mg and Finasteride 1mg, the user still experiences hair loss, particularly miniaturized hairs in the mid-scalp area, along with itching. They are concerned about losing around 40 hairs daily despite treatment.

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