Development and Evaluation of Finasteride Niosomes Targeting Hair Follicles for Androgenic Alopecia Management

    Fei Liu, Feng Guo, Desheng Liang, Fulin Li, Yating Cao, Mengqi Chen, Jianjun Xu, Xinliang Liu, Haijun Zhong
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    TLDR Finasteride niosomes were developed and found to be effective in treating hair loss, with better results than commercial minoxidil, and could be a promising topical treatment for hair loss.
    The study developed and evaluated finasteride niosomes (FIN-NIS) as a dermal delivery system for the treatment of androgenetic alopecia (AGA), a common hair loss disorder. Finasteride, an oral drug that inhibits the conversion of testosterone to dihydrotestosterone, has been used to treat AGA, but long-term oral administration can lead to serious systemic side effects. The researchers found that FIN-NIS enhanced finasteride permeation and retention, particularly increasing drug concentration in hair follicles. The therapeutic efficacy of FIN-NIS on testosterone-induced AGA mice was higher than that of commercial minoxidil in terms of hair regrowth and anagen restoration. Therefore, FIN-NIS could be a promising dermal topical delivery system for the treatment of AGA.
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      in Finasteride  71 upvotes 5 days ago
      The user has been using finasteride and minoxidil for 8-9 months without significant improvement in hair loss and is considering switching to dutasteride and topical minoxidil. Another user suggests that dutasteride might be more effective due to its potency and advises patience as hair regrowth can take up to a year.

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      in Finasteride  102 upvotes 1 week ago
      An 18-year-old using topical finasteride for hair loss is experiencing side effects like delayed ejaculation and lower sex drive after three months. They are considering whether to continue with the treatment or adjust it, possibly switching back to minoxidil.

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      in Finasteride  68 upvotes 1 week ago
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