Three-Dimensional Proteome-Wide Scale Screening for the 5-Alpha Reductase Inhibitor Finasteride: Identification of a Novel Off-Target

    April 2021 in “ Journal of Medicinal Chemistry
    Silvia Giatti, Alessandro Di Domizio, Silvia Diviccaro, Eva Falvo, Donatella Caruso, Alessandro Contini, Roberto Cosimo Melcangi
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    TLDR Finasteride may affect PNMT, causing side effects.
    The study aimed to identify new off-target effects of the hair loss drug finasteride through proteome-wide scale screening. The study found a new potential off-target called PNMT, which could contribute to the drug's side effects. The study emphasizes the importance of understanding drug side effects and the need for further research to improve drug safety.
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