Three-Dimensional Proteome-Wide Scale Screening for the 5-Alpha Reductase Inhibitor Finasteride: Identification of a Novel Off-Target

April 2021 in “ Journal of Medicinal Chemistry ”

Silvia Giatti, Alessandro Di Domizio, Silvia Diviccaro, Eva Falvo, Donatella Caruso, Alessandro Contini, Roberto Cosimo Melcangi

finasteride 5-alpha reductase inhibitor PNMT Propecia

TLDR Finasteride may affect PNMT, causing side effects.

The study aimed to identify new off-target effects of the hair loss drug finasteride through proteome-wide scale screening. The study found a new potential off-target called PNMT, which could contribute to the drug's side effects. The study emphasizes the importance of understanding drug side effects and the need for further research to improve drug safety.

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Research cited in this study

17 / 17 results

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The review suggests younger men taking 1 mg finasteride report more side effects, including sexual, skin, metabolic, and psychological issues.

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Personalized treatment with inhibitors, minoxidil, and laser therapy helps hair loss.

research Assessing Finasteride-Associated Sexual Dysfunction Using the FAERS Database

24 citations , March 2017 in “Journal of The European Academy of Dermatology and Venereology”

Finasteride use linked to increased risk of sexual dysfunction, especially in younger people.

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32 citations , February 2016 in “Journal of Dermatology”

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33 citations , December 2015 in “Neuroendocrinology”

Finasteride treatment changes brain steroid levels and receptors, affecting brain function even after stopping treatment.

research Adverse Event Reporting in Clinical Trials of Finasteride for Androgenic Alopecia: A Meta-Analysis

44 citations , April 2015 in “PubMed”

Finasteride for hair loss may cause long-lasting side effects like impotence and low libido, but trials lack proper safety reporting.

research Depressive Symptoms and Suicidal Thoughts Among Former Users of Finasteride With Persistent Sexual Side Effects

134 citations , August 2012 in “The Journal of Clinical Psychiatry”

Former finasteride users with persistent sexual side effects have higher rates of depression and suicidal thoughts.

research Inhibition of Human Steroid 5β-Reductase (AKR1D1) by Finasteride and Structure of the Enzyme-Inhibitor Complex

47 citations , June 2009 in “Journal of Biological Chemistry”

Finasteride helps treat hair loss and prostate enlargement by blocking a specific enzyme.

research Depression Related to Finasteride Administration for Androgenetic Alopecia

88 citations , October 2002 in “Journal of Dermatology”

Finasteride for hair loss may cause depression, affecting sleep and relationships.

research Finasteride in the Treatment of Men with Androgenetic Alopecia

581 citations , October 1998 in “Journal of The American Academy of Dermatology”

Finasteride safely and effectively treats male pattern hair loss, but may cause reversible sexual issues and harm male fetuses.

Effects of the 5α-Reductase Inhibitor Finasteride on Serum Levels of Gonadal, Adrenal, and Hypophyseal Hormones and Its Clinical Significance: A Prospective Clinical Study

research Effects of the 5α-Reductase Inhibitor Finasteride on Serum Levels of Gonadal, Adrenal, and Hypophyseal Hormones and Its Clinical Significance: A Prospective Clinical Study

56 citations , April 1998 in “Steroids”

Finasteride reduces hair loss and treats BPH without major hormone changes, but may cause sexual dysfunction.

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