Niosomal And Ethosomal Gels: A Comparative In Vitro And Ex Vivo Evaluation For Repurposing Of Spironolactone

    July 2022 in “ Journal of Drug Delivery Science and Technology ”
    Heba M.I. Abdallah, Nagia A. El-Megrab, Gehan F. Balata, Noura G. Eissa
    Studysummary This study found that Spironolactone-loaded ethosomal gels provided superior skin permeation and deposition compared to niosomal gels in rabbit skin, suggesting that ethosomal gels could be a promising formulation for further clinical studies on treating androgenic alopecia.
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    Research cited in this study 8

    1. Follicular-Targeted Delivery of Spironolactone Provided by Polymeric Nanoparticles Colloids and surfaces. B, Biointerfaces · 2021
    2. A Novel Approach for Follicular Delivery of Minoxidil for Treatment of Alopecia Journal of Drug Delivery Science and Technology · 2017
    3. Demographics of Women with Female Pattern Hair Loss and the Effectiveness of Spironolactone Therapy Journal of The American Academy of Dermatology · 2015
    4. Follicular Delivery of Spironolactone via Nanostructured Lipid Carriers for Management of Alopecia International Journal of Nanomedicine · 2014
    5. Niosomes as a Vesicular Carrier for Topical Administration of Minoxidil: Formulation and In Vitro Assessment Drug Delivery and Translational Research · 2013
    6. Formulation and In Vitro Assessment of Minoxidil Niosomes for Enhanced Skin Delivery International Journal of Pharmaceutics · 2009
    7. Treatment of Female Pattern Hair Loss With Oral Antiandrogens British Journal of Dermatology · 2005
    8. Topical Treatment of Androgenetic Alopecia with Spironolactone Journal of The European Academy of Dermatology and Venereology · 1997

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    1. Niosomes as a Vesicular Carrier for Topical Administration of Minoxidil: Formulation and In Vitro Assessment Drug Delivery and Translational Research · 2013