Niosomal And Ethosomal Gels: A Comparative In Vitro And Ex Vivo Evaluation For Repurposing Of Spironolactone
July 2022
in “
Journal of Drug Delivery Science and Technology
”
TLDR Niosomes and ethosomes can effectively carry the drug spironolactone, potentially improving treatment for hair loss and reducing side effects.
The study "Niosomal and ethosomal gels: A comparative in vitro and ex vivo evaluation for repurposing of spironolactone" explores the use of niosomes and ethosomes as nanocarriers for the delivery of spironolactone (Spn), a drug with antiandrogenic properties that has shown success in reducing androgenic alopecia (Aga). The study found that both niosomes and ethosomes encapsulated Spn effectively, with entrapment efficiency of 95–97.3% and 61.5–96.9% respectively. This suggests that these nanovesicular systems could be promising for future skin delivery of Spn for the management of Aga, potentially minimizing side effects associated with oral administration of the drug.
