Spironolactone May Reduce the Risk of Incident Rosacea

    April 2013 in “ Journal of Investigative Dermatology ”
    Julia Spoendlin, Johannes J. Voegel, Susan S. Jick, Christoph Meier
    Image of study
    TLDR Spironolactone might lower the chance of getting rosacea.
    In 2013, a large population-based case-control study using the UK-based General Practice Research Database examined the effect of spironolactone on the risk of developing rosacea. The study involved 53,927 patients with a new diagnosis of rosacea and an equal number of controls without the condition. The findings indicated that spironolactone use was linked to a reduced risk of rosacea, with an adjusted odds ratio of 0.83 for spironolactone users, which decreased to 0.47 among current users at the index date. This suggested that spironolactone's anti-androgenic effects might contribute to the lower risk, though the precise mechanism was not determined. Despite being the largest study of its kind, the authors acknowledged the possibility of residual confounding factors.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 409 results

      community Spironolactone and pregnancy planning

      in Female  2 upvotes 1 month ago
      A user with AGA uses topical spironolactone 2% due to side effects from the oral form and is concerned about its use during conception and breastfeeding. They seek alternatives to prevent AGA relapse while planning pregnancy and after childbirth.

      community spironolactone pills to topical

      in Research/Science  6 upvotes 1 month ago
      Crushing spironolactone pills and combining them with minoxidil for topical application may be effective for hair loss, with the addition of finasteride suggested. Adding rosemary and peppermint oils can help mask the unpleasant smell.

      community Does the effect of spironolactone on androgenetic alopecia really weaken over time?

      in Female  4 upvotes 3 months ago
      Spironolactone can remain effective for a long time in treating androgenetic alopecia, but it may not completely stop hair loss. Hair loss treatments like spironolactone, finasteride, and dutasteride slow down hair loss rather than cure it, and their effectiveness can vary based on individual response and the aggressiveness of the condition.

      community Spironolactone VS dutasteride for female pattern hair loss

      in Treatment  7 upvotes 9 months ago
      Spironolactone is more potent and lowers testosterone and DHT, while dutasteride only impacts DHT. For female hair loss, checking hormones and considering treatments like oral minoxidil, spironolactone, or topical minoxidil is recommended.

      community Spironolactone, what do you think?

      in Finasteride/Dutasteride  4 upvotes 10 months ago
      A user is considering Spironolactone for hair loss but is advised against it due to its effects on testosterone. Instead, they are recommended to try finasteride at 18 and consider dutasteride if needed.

    Similar Research

    5 / 1000+ results
      Hormone Therapy in Acne

      research Hormone Therapy in Acne

      24 citations, January 2013 in “Indian Journal of Dermatology, Venereology and Leprology”
      Hormonal treatment is effective for women with acne not helped by usual treatments, especially if they have hormonal imbalances.
      Clinical Updates in Hair

      research Clinical Updates in Hair

      19 citations, January 1997 in “Dermatologic Clinics”
      Most treatments for hair loss in 1997 were not effective for most people, and maintaining hair growth was difficult.