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GlossaryLipophilic Drugs

dissolve in fats and easily cross cell membranes

Lipophilic drugs, also known as fat-soluble drugs, are medications that dissolve in fats, oils, and lipids rather than water. This property allows them to easily cross cell membranes, which are composed of lipid bilayers, facilitating their absorption and distribution within the body. These drugs often have longer half-lives and can accumulate in fatty tissues, potentially leading to prolonged effects or toxicity.

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Transfollicular Drug Delivery: Penetration of Drugs Through Human Scalp Skin and Comparison of Penetration Between Scalp and Abdominal Skins In Vitro

research Transfollicular Drug Delivery: Penetration of Drugs Through Human Scalp Skin and Comparison of Penetration Between Scalp and Abdominal Skins In Vitro

82 citations, January 2002 in “Journal of drug targeting”

Drugs penetrate scalp skin better than abdominal skin, with scalp hair follicles aiding in higher drug delivery.

research Invasomes: Vesicles for Enhanced Skin Delivery of Drugs

6 citations, January 2016 in “Springer eBooks”

Invasomes effectively deliver drugs through the skin and have potential for improved treatments.

research Recent Studies on the Delivery of Hydrophilic Drugs in Nanoparticulate Systems

47 citations, September 2015 in “Journal of Drug Delivery Science and Technology”

Nanoparticulate systems improve drug delivery by controlling release, protecting drugs, changing absorption and distribution, and concentrating drugs in targeted areas.

research Nanoporous Silica Entrapped Lipid-Drug Complexes for the Solubilization and Absorption Enhancement of Poorly Soluble Drugs

8 citations, January 2021 in “Pharmaceutics”

Nanoporous silica entrapped lipid-drug complexes significantly improve the solubility and absorption of drugs that don't dissolve well in water.

research Nanoemulgel: For Promising Topical and Systemic Delivery

5 citations, April 2022 in “IntechOpen eBooks”

Nanoemulgel is a better way to deliver drugs through the skin for various conditions.

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community Topical Dutasteride & Microneedling Works

in Finasteride/Dutasteride 5 upvotes 2 months ago

Topical dutasteride, especially at higher concentrations, can be effective for hair loss when combined with microneedling to enhance absorption. Users discuss the side effects of finasteride and dutasteride, with some preferring topical treatments to avoid systemic side effects.

community Soundwaves & Electricity Grows Hair? | Peptide Delivery Model.

in Research/Science 2 upvotes 3 months ago

Iontophoresis and sonophoresis can enhance drug delivery into the scalp. Combining these methods may improve the effectiveness of topical treatments like dutasteride and certain peptides.

community Topical fin and min and swallowing semen

in Finasteride/Dutasteride 118 upvotes 5 months ago

A user asked if it's safe to swallow semen from a partner using topical finasteride and minoxidil. Responses varied, but most suggested it's likely safe, with minimal risk from small amounts of finasteride in semen.

community My hair loss theory and what I did to stop my hair loss. 6 years of stabilization.

in Treatment 7 upvotes 4 years ago

A user shared their personal theory on hair loss, suggesting it's caused by reduced blood flow and scalp calcification rather than DHT, and claimed to have stopped their hair loss by massaging the scalp, using acid peels, and applying oils and copper peptides. They have not noticed further hair loss for six years since starting this routine.

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

in Research/Science 71 upvotes 4 months ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

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