The Influence of Sebaceous Content on the Performance of Nanosystems Designed for the Treatment of Follicular Diseases

July 2020 in “ Journal of Drug Delivery Science and Technology ”

Seila Tolentino, Maíra N. Pereira, Mikaella C. de Sousa, Marcilio Cunha-Filho, Guilherme M. Gelfuso, Tais Gratieri, Seila Tolentino, Maíra N. Pereira, Mikaella C. de Sousa, Marcilio Cunha-Filho, Guilherme M. Gelfuso, Tais Gratieri

sebaceous content nanosystems hair follicle sebum nanoparticles nanostructured lipid carrier clindamycin phosphate folliculitis acne topical drug delivery clindamycin

TLDR Excess sebum reduces the effectiveness of nanosystems for treating hair follicle conditions.

The study investigated the impact of sebaceous content on the effectiveness of nanosystems for treating hair follicle-related conditions. Using an in vitro sebaceous skin model, researchers found that excess sebum, mimicking conditions like acne and folliculitis, hindered the deposition of nanoparticles into hair follicle shafts. A nanostructured lipid carrier with clindamycin phosphate showed superior performance in conventional skin models but not in the sebaceous model. This highlighted the importance of considering physiological skin conditions when designing drug delivery systems. The study introduced a novel sebaceous skin model for more realistic evaluation of topical drug delivery in conditions with excess sebum secretion.

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