The Influence of Sebaceous Content on the Performance of Nanosystems Designed for the Treatment of Follicular Diseases

July 2020 in “ Journal of Drug Delivery Science and Technology ”

Seila Tolentino, Maíra N. Pereira, Mikaella C. de Sousa, Marcilio Cunha-Filho, Guilherme M. Gelfuso, Tais Gratieri, Seila Tolentino, Maíra N. Pereira, Mikaella C. de Sousa, Marcilio Cunha-Filho, Guilherme M. Gelfuso, Tais Gratieri

sebaceous content nanosystems hair follicle sebum nanoparticles nanostructured lipid carrier clindamycin phosphate folliculitis acne topical drug delivery clindamycin

TLDR Excess sebum reduces the effectiveness of nanosystems for treating hair follicle conditions.

The study investigated the impact of sebaceous content on the effectiveness of nanosystems for treating hair follicle-related conditions. Using an in vitro sebaceous skin model, researchers found that excess sebum, mimicking conditions like acne and folliculitis, hindered the deposition of nanoparticles into hair follicle shafts. A nanostructured lipid carrier with clindamycin phosphate showed superior performance in conventional skin models but not in the sebaceous model. This highlighted the importance of considering physiological skin conditions when designing drug delivery systems. The study introduced a novel sebaceous skin model for more realistic evaluation of topical drug delivery in conditions with excess sebum secretion.

View this study on sciencedirect.com →

Discuss this study in the Community →

Research cited in this study

11 / 11 results

research Solid Effervescent Formulations as a New Approach for Topical Minoxidil Delivery

33 citations , October 2016 in “European Journal of Pharmaceutical Sciences”

Effervescent formulations may improve minoxidil delivery, increasing effectiveness and reducing applications needed.

research Minoxidil Topical Treatment May Be More Efficient If Applied on Damp Scalp Compared to Dry Scalp

13 citations , June 2016 in “Dermatologic Therapy”

Minoxidil works better when applied on a damp scalp than a dry one.

research Hidradenitis Suppurativa/Acne Inversa: An Endocrine Skin Disorder?

41 citations , June 2016 in “Reviews in endocrine and metabolic disorders”

Hidradenitis suppurativa may be related to hormones and patients often have metabolic disorders; more research is needed to understand this connection.

research Hair Follicles as a Target Structure for Nanoparticles

59 citations , July 2015 in “Journal of innovative optical health sciences/Journal of innovation in optical health science”

Nanoparticles around 600-700 nm can effectively enter and stay in hair follicles for days, which may help in delivering drugs to specific cells.

research Chitosan Nanoparticles for Targeting and Sustaining Minoxidil Sulphate Delivery to Hair Follicles

77 citations , January 2015 in “International Journal of Biological Macromolecules”

Chitosan nanoparticles improve minoxidil delivery to hair follicles for better alopecia treatment.

research Self-Assembled Polymeric Nanocarriers for the Targeted Delivery of Retinoic Acid to the Hair Follicle

59 citations , January 2015 in “Nanoscale”

The new micelle formulation delivers acne treatment more effectively and safely than current gels.

research Iontophoresis-Targeted, Follicular Delivery of Minoxidil Sulfate for the Treatment of Alopecia

32 citations , March 2013 in “Journal of Pharmaceutical Sciences”

Iontophoresis improves minoxidil delivery for alopecia treatment.

research Human Hair Follicle: Reservoir Function and Selective Targeting

97 citations , September 2011 in “British Journal of Dermatology”

The human hair follicle can store topical compounds and be targeted for drug delivery with minimal side effects.

research Chitosan Microparticles for Sustaining the Topical Delivery of Minoxidil Sulphate

45 citations , August 2011 in “Journal of Microencapsulation”

Chitosan microparticles improve minoxidil sulphate delivery, potentially reducing daily applications.

research Investigation of the Penetration and Storage of a Shampoo Formulation Containing Caffeine into the Hair Follicles by In Vivo Laser Scanning Microscopy

24 citations , February 2007 in “Laser Physics Letters”

Caffeine shampoo penetrates hair follicles deeply and stays for up to 48 hours.

research Biology of the Hair Follicle: The Basics

224 citations , March 2006 in “Seminars in Cutaneous Medicine and Surgery”

The document concludes that understanding hair follicle biology can lead to better hair loss treatments.

Related Community Posts Join

6 / 91 results

community DHT Harms Scalp Microbiome: DHT Itch is REAL

in Research/Science 415 upvotes 7 months ago

Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

community The most nuclear stack possible

in Satire 43 upvotes 8 months ago

A user humorously suggests an extreme hair loss treatment regimen involving multiple medications and therapies, including Dutasteride, Minoxidil, RU58841, and others, claiming it would prevent hair loss but with potential side effects like gynecomastia. The conversation highlights concerns about safety, side effects, and the effectiveness of such a comprehensive approach.

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens.

in Research/Science 2 upvotes 11 months ago

A method for treating androgenic alopecia using minoxidil, antiandrogens, exercise, and cold exposure to promote hair growth. Environmental factors and lifestyle changes, like diet and exercise, can improve treatment effectiveness.

community Is this real chat? Finasteride -> fountain of youth and longevity drug?

in Finasteride/Dutasteride 558 upvotes 2 months ago

Finasteride is discussed as a hair loss treatment with benefits like reduced prostate enlargement and skin aging, but it is not seen as a "fountain of youth." Users report mixed experiences, including side effects like decreased libido and dry eyes.

community DUPA/Retrograde might not be DHT based...GET A BIOPSY QUICK or permanent Hair Loss!

in Research/Science 43 upvotes 9 months ago

DUPA and retrograde alopecia may not be solely DHT-based, and a biopsy is crucial for accurate diagnosis and treatment. Treatments mentioned include dutasteride, oral minoxidil, pioglitazone, clobetasol, calcipotriol, ketoconazole, and doxycycline, depending on the specific condition.

Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

in Research 413 upvotes 11 months ago

Treating androgenic alopecia with minoxidil, finasteride, and antiandrogens, alongside exercise, cryotherapy, and natural substances to stimulate cold receptors for better hair growth. The method focuses on enhancing treatment effectiveness by considering environmental and behavioral factors and the role of cold receptors and muscle stress.

Related Research

2 / 2 results

research Hair Disorders

October 2018 in “Springer eBooks”

The document concludes that various hair disorders have different treatments, including medication, surgery, and addressing underlying causes.

research Culture of the Human Pilosebaceous Unit, Hair Follicle, and Sebaceous Gland

30 citations , April 2018 in “Experimental Dermatology”

The article concludes that developing in vitro models for human hair structures is important for research and reducing animal testing, but there are challenges like obtaining suitable samples and the models' limitations.