Investigation of the Penetration and Storage of a Shampoo Formulation Containing Caffeine into the Hair Follicles by In Vivo Laser Scanning Microscopy

February 2007 in “ Laser Physics Letters ”

A. Teichmann, Heike Richter, Fanny Knorr, Ch. Antoniou, Wolfram Sterry, Jürgen Lademann

caffeine hair follicles in vivo laser scanning microscopy dermatopharmacokinetics topically applied substances

The study investigated the penetration of a caffeine-containing shampoo into hair follicles using in vivo laser scanning microscopy. It was found that a 2-minute contact time allowed the formulation to penetrate deeply into the follicles and remain for up to 48 hours, even after washing. This highlighted hair follicles as significant targets for drug delivery due to their surrounding capillary network. The study also demonstrated the effectiveness of in vivo laser scanning microscopy in analyzing the dermatopharmacokinetics of topically applied substances.

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Research cited in this study

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research Follicular Penetration of Topically Applied Caffeine via a Shampoo Formulation

93 citations , January 2007 in “Skin Pharmacology and Physiology”

The study investigated the follicular penetration of caffeine when applied topically via a shampoo formulation for 2 minutes. Using surface ionization and mass spectroscopy, it was determined that caffeine penetrated through both hair follicles and the stratum corneum. The results indicated that penetration through hair follicles was faster and more significant compared to the interfollicular route, establishing that hair follicles were the primary pathway for rapid caffeine absorption within the first 20 minutes post-application.

research Effect of Caffeine and Testosterone on the Proliferation of Human Hair Follicles In Vitro

114 citations , January 2007 in “International Journal of Dermatology”

The study investigated the effects of testosterone and caffeine on human hair follicles in vitro, using samples from 14 male patients with androgenetic alopecia (AGA). Testosterone at 5 µg/ml significantly suppressed hair follicle growth, but this effect was counteracted by caffeine at concentrations of 0.001% and 0.005%. Caffeine alone also significantly stimulated hair follicle growth. These findings, confirmed by Ki-67 staining, suggested that caffeine could be a potential stimulator of hair growth and may have clinical implications for managing AGA.

research Follicular Targeting: A Promising Tool in Selective Dermatotherapy

109 citations , November 2005 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

Targeting hair follicles can improve skin treatments and reduce side effects.

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community A meta analysis of 18 popular hair loss treatments. An 2022 guide on efficacy. From finasteride and minoxidil to caffeine shampoo, saw palmetto and biotin. 96 Scientific References included.

in Research/Science 103 upvotes 3 years ago

Most hair loss treatments are ineffective; only finasteride, dutasteride, and minoxidil show effectiveness.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Dr Huberman - Cafeine when rubbed on the scalp can be as effective at times as minoxidil because it triggers 1GF-1

in Update 267 upvotes 2 years ago

Whether topical caffeine can be as effective for hair growth as minoxidil and finasteride, with various replies discussing the efficacy of these treatments and criticism of Dr. Huberman's research methods.

community Creatine Doesn’t Cause Hair Loss: Stop the BS

in Research/Science 136 upvotes 1 month ago

Creatine does not cause hair loss, despite many users reporting personal experiences of hair shedding. Scientific evidence shows no link between creatine and increased hair loss or hormone changes.

community Theoretically won't this be better than finasteride? Azelaic acid + zinc

in Research/Science 9 upvotes 2 years ago

The conversation discusses using zinc sulphate and azelaic acid to inhibit 5 alpha-reductase activity, which could potentially treat androgen-related skin conditions like hair loss. Combining these with vitamin B6 could enhance the effect, potentially offering an alternative to finasteride.

community Scientific Review: Caffeine shampoo does NOT stop hair loss. False claims and "fake" research. 19 References included.

in Research/Science 207 upvotes 3 years ago

Alpecin Caffeine shampoo is ineffective for stopping hair loss, with unreliable supporting research. Finasteride is effective in reducing hair loss by lowering DHT levels.

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research Shampoo, Conditioner, and Hair Washing

1 citations , December 2021 in “International journal of research in dermatology”

Dermatologists should learn more about shampoos to better treat hair and scalp issues.