Search

for
Search:

Did you mean Lipophilicity?

GlossaryLipophilicity

chemical affinity for dissolving in fats and oils

Lipophilicity refers to the chemical property of a substance that describes its ability to dissolve in fats, oils, and lipids rather than in water. This characteristic is crucial in pharmacology and biochemistry because it influences how drugs are absorbed, distributed, and retained in the body, as well as their ability to cross cell membranes.

Related Terms

Learn

0 / 0 results

— no results

Research

5 / 1000+ results

research Establishment of an Evaluation Method to Detect Drug Distribution in Hair Follicles

7 citations , February 2018 in “International Journal of Pharmaceutics”

Researchers developed a method to measure drugs in hair follicles and found that both water-loving and fat-loving drugs can be detected after being applied to the skin.

research Ethosome: A Novel Vesicular Carrier for Transdermal Drug Delivery

14 citations , November 2018 in “Journal of drug delivery and therapeutics”

Ethosomes are effective, safe carriers for delivering drugs through the skin.

research Improvement of Hair Damage by Lipophilic Vitamin C (Ascorbyl Tetraisopalmitate)

September 2018 in “Journal of Society of Cosmetic Chemists of Japan”

Lipophilic Vitamin C improves damaged hair texture and condition.

research A Critical Review: Recent Advances in Ethosomal Gel for Transdermal Drug Delivery Systems

January 2026 in “Zenodo (CERN European Organization for Nuclear Research)”

Ethosomal gels improve drug delivery through the skin, enhancing treatment effectiveness.

research Optimized Skin Optical Clearing for Optical Coherence Tomography Monitoring of Encapsulated Drug Delivery Through the Hair Follicles

19 citations , January 2020 in “Journal of Biophotonics”

A PEG-400/oleic acid mixture best improves drug delivery monitoring through hair follicles.

View more "lipophilic" in research →

Community Join

5 / 46 results

community Currently crushing 3 (5mg) tablets of fin into my topical min. Anyone do the same? If so how much do you add.

in Treatment 186 upvotes 1 year ago

The conversation discusses using crushed finasteride tablets mixed with topical minoxidil for hair loss treatment. Users share their experiences and opinions on the effectiveness and proper concentration of this method.

community Topical fin and min and swallowing semen

in Finasteride/Dutasteride 118 upvotes 1 year ago

A user asked if it's safe to swallow semen from a partner using topical finasteride and minoxidil. Responses varied, but most suggested it's likely safe, with minimal risk from small amounts of finasteride in semen.

community Why is dutasteride's volume of distribution so much bigger than finasteride? Is it more lipophilic and crosses barriers better?

in Finasteride/Dutasteride 24 upvotes 1 year ago

Dutasteride has a larger volume of distribution than finasteride due to its lipophilic nature, allowing it to concentrate in hydrophobic areas and making it difficult to excrete. A user experiencing hair loss has been using oral finasteride for 10 months with minimal regrowth and is considering switching to dutasteride or adding oral minoxidil.

community Does melatonin dissolve in isopropyl alcohol

in Technology 6 upvotes 3 years ago

The conversation discusses making a topical melatonin solution for hair loss treatment, questioning if isopropyl alcohol can dissolve melatonin. Melatonin is soluble in lipids and alcohol, but it's unstable and should be mixed fresh regularly; it may help hair growth by affecting certain cellular signaling pathways and has anti-androgenic effects.

community Topical Dutasteride - Non-Hormonal, Side Effect Free 5ARI?

4chanhrn in Treatments 451 upvotes 1 year ago

Topical dutasteride is suggested as a low side-effect treatment for hair loss, with a proposed dose of 0.025% 1ml/day. It is considered better than finasteride due to its even inhibition of DHT isoforms and lower systemic absorption.

View more "lipophilic" in community →