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    Glossary Lipophilicity

    chemical affinity for dissolving in fats and oils

    Lipophilicity refers to the chemical property of a substance that describes its ability to dissolve in fats, oils, and lipids rather than in water. This characteristic is crucial in pharmacology and biochemistry because it influences how drugs are absorbed, distributed, and retained in the body, as well as their ability to cross cell membranes.

    Research 10 of 295

    1. Permeant lipophilicity and vehicle composition influence accumulation of dyes in hair follicles of human skin European journal of pharmaceutical sciences · 2003 · 44 citations
    2. Penetration and distribution of three lipophilic probes in vitro in human skin focusing on the hair follicle Journal of controlled release · 2002 · 54 citations
    3. A discourse on human hair fibers and reflections on the conservation of drug molecules International Journal of Legal Medicine · 1996 · 47 citations
    4. Contribution of the Hair Follicular Pathway to Total Skin Permeation of Topically Applied and Exposed Chemicals Pharmaceutics · 2016 · 39 citations
    5. Stability of polylactic acid particles and release of fluorochromes upon topical application on human skin explants European journal of pharmaceutics and biopharmaceutics · 2011 · 31 citations
    6. Diffusion properties of model compounds in artificial sebum International journal of pharmaceutics · 2007 · 29 citations
    7. Biological activity of novel progesterone derivatives having a bulky ester side chains at C-3 Steroids · 2008 · 15 citations
    8. Impact of Ester Promoieties on Transdermal Delivery of Ketorolac Journal of Pharmaceutical Sciences · 2014 · 10 citations
    9. Synthesis and biological evaluation of esters of 16-formyl-17-methoxy-dehydroepiandrosterone derivatives as inhibitors of 5α-reductase type 2 Journal of Enzyme Inhibition and Medicinal Chemistry · 2015 · 5 citations
    10. Evaluation of Skin Penetration of Fluorescent Dissolved Formulations Using Confocal Laser Scanning Microscopy Pharmaceutics · 2025 · 2 citations
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