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    Glossary Lipophilicity

    chemical affinity for dissolving in fats and oils

    Lipophilicity refers to the chemical property of a substance that describes its ability to dissolve in fats, oils, and lipids rather than in water. This characteristic is crucial in pharmacology and biochemistry because it influences how drugs are absorbed, distributed, and retained in the body, as well as their ability to cross cell membranes.

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    1. Permeant lipophilicity and vehicle composition influence accumulation of dyes in hair follicles of human skin European journal of pharmaceutical sciences · 2003 · 44 citations
    2. Penetration and distribution of three lipophilic probes in vitro in human skin focusing on the hair follicle Journal of controlled release · 2002 · 54 citations
    3. A discourse on human hair fibers and reflections on the conservation of drug molecules International Journal of Legal Medicine · 1996 · 47 citations
    4. Contribution of the Hair Follicular Pathway to Total Skin Permeation of Topically Applied and Exposed Chemicals Pharmaceutics · 2016 · 39 citations
    5. Stability of polylactic acid particles and release of fluorochromes upon topical application on human skin explants European journal of pharmaceutics and biopharmaceutics · 2011 · 31 citations
    6. Diffusion properties of model compounds in artificial sebum International journal of pharmaceutics · 2007 · 29 citations
    7. Biological activity of novel progesterone derivatives having a bulky ester side chains at C-3 Steroids · 2008 · 15 citations
    8. Impact of Ester Promoieties on Transdermal Delivery of Ketorolac Journal of Pharmaceutical Sciences · 2014 · 10 citations
    9. Synthesis and biological evaluation of esters of 16-formyl-17-methoxy-dehydroepiandrosterone derivatives as inhibitors of 5α-reductase type 2 Journal of Enzyme Inhibition and Medicinal Chemistry · 2015 · 5 citations
    10. Evaluation of Skin Penetration of Fluorescent Dissolved Formulations Using Confocal Laser Scanning Microscopy Pharmaceutics · 2025 · 2 citations
    11. Penetration and Distribution in Human Skin Focusing on the Hair Follicle CRC Press eBooks · 2005 · 1 citations
    12. In Silico Study on the Contribution of the Follicular Route to Dermal Permeability of Small Molecules Pharmaceutical research · 2024
    13. Photo-responsive fibers as artificial hairs in an in-vitro model for transdermal drug delivery Research Portal Denmark · 2024
    14. Related Topic: Drug Permeation Through Hair Follicles Springer eBooks · 2017 · 1 citations
    15. An Investigation of Hair and its Keratin Associated Proteins using Advanced Light Microscopy Durham e-Theses (Durham University) · 2019
    16. Hair follicle targeting with curcumin nanocrystals: Influence of the formulation properties on the penetration efficacy Journal of Controlled Release · 2020 · 60 citations
    17. Dermal Delivery of Topically Applied Oligonucleotides via Follicular Transport in Mouse Skin Journal of Investigative Dermatology · 2005 · 64 citations
    18. Absorption sites of orally administered drugs in the small intestine Expert Opinion on Drug Discovery · 2017 · 55 citations
    19. Modulation of the 6-position of benzopyran derivatives and inhibitory effects on the insulin releasing process Bioorganic & Medicinal Chemistry · 2011 · 13 citations
    20. Targeted skin delivery of topically applied drugs by optimised formulation design 2016 · 2 citations
    21. Applications and limitations of lipid nanoparticles in dermal and transdermal drug delivery via the follicular route European journal of pharmaceutics and biopharmaceutics · 2015 · 95 citations
    22. The application prospects of honokiol in dermatology Dermatologic Therapy · 2022 · 6 citations
    23. Skin applications of cannabidiol: sources, effects, delivery systems, marketed formulations and safety Phytochemistry Reviews · 2023 · 1 citations
    24. Coenzyme Q10 phospholipidic vesicular formulations for treatment of androgenic alopecia: <i>ex vivo</i> permeation and clinical appraisal Figshare · 2021
    25. Squalene-Containing Nanostructured Lipid Carriers Promote Percutaneous Absorption and Hair Follicle Targeting of Diphencyprone for Treating Alopecia Areata Pharmaceutical Research · 2012 · 59 citations
    26. NANOEMULGEL AS A RECENT DRUG DELIVERY SYSTEM Military Medical Science Letters · 2021 · 8 citations
    27. Dermal and Transdermal Drug Delivery through Vesicles and Particles: Preparation and Applications Advanced Pharmaceutical Bulletin · 2021 · 33 citations
    28. (1R,2S)-4-(2-Cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile, a potent androgen receptor antagonist for stimulating hair growth and reducing sebum production Bioorganic & Medicinal Chemistry Letters · 2007 · 14 citations
    29. Establishment of an evaluation method to detect drug distribution in hair follicles International Journal of Pharmaceutics · 2018 · 7 citations
    30. ANDROGRAPHOLIDE LOADED TOPICAL NANOCARRIERS FOR MANAGEMENT OF PSORIASIS: A SAFE AND EFFECTIVE APPROACH PLANT ARCHIVES · 2021 · 2 citations