Are we underestimating systemic absorption with homemade/generic Topical Fin? (HPCH vs. PG/Ethanol formulations)
    Research/Science 1/27/2026

    At a glance
    In this research discussion post, the primary subjects mentioned are
    ๐Ÿ’Š Dutasteride (oral) 0.5mg
    ๐Ÿ’Š Minoxidil (oral)
    ๐Ÿ’ง Finasteride (topical)
    the tone is ๐Ÿ˜ neutral.

    Other terms

    Topical finasteride may have higher systemic absorption and lower efficacy when using a Propylene Glycol/Ethanol formulation compared to the hydroxypropyl chitosan (HPCH) formulation. The safety profile of topical finasteride relies heavily on the HPCH formulation, and using standard solutions might lead to different pharmacokinetics.
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