Efficacy and Safety of Topical Finasteride Spray Solution in the Treatment of Chinese Men with Androgenetic Alopecia: A Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study

    March 2025 in “ Chinese Medical Journal ”
    Cheng Zhou, Bin Yang, Huiming Zeng … Jianzhong Zhang
    Studysummary This randomized, double-blind, placebo-controlled phase III trial found that a 24-week treatment with topical finasteride significantly increased hair growth and was well-tolerated in Chinese men with androgenetic alopecia compared to placebo.
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    Research cited in this study 46

    1. Mechanism and Clinical Efficacy of Peripheral Blood Alive Cell Treatment on Androgenic Alopecia Chinese Medical Journal · 2024
    2. Patient-Reported Outcomes of Topical Finasteride/Minoxidil Treatment for Male Androgenetic Alopecia: A Retrospective Study Using Telemedical Data Journal of cosmetic dermatology · 2024
    3. Oral Minoxidil Versus Topical Minoxidil for Male Androgenetic Alopecia JAMA dermatology · 2024
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    6. Treatment of Androgenetic Alopecia: Current Guidance and Unmet Needs Clinical, Cosmetic and Investigational Dermatology · 2023
    7. Human Stem Cell Use in Androgenetic Alopecia: A Systematic Review Cells · 2023
    8. Comparison Between Topical Cetirizine With Minoxidil Versus Topical Placebo With Minoxidil In Female Androgenetic Alopecia: A Randomized, Double-Blind, Placebo-Controlled Study Archives of Dermatological Research · 2022
    9. Comorbidities in Androgenetic Alopecia: A Comprehensive Review Dermatology and therapy · 2022
    10. Comparison of Oral Minoxidil, Finasteride, and Dutasteride for Treating Androgenetic Alopecia Journal of Dermatological Treatment · 2022
    11. A Study of Combination Unilateral Subcutaneous Botulinum Toxin A Treatment for Androgenetic Alopecia Journal of Cosmetic Dermatology · 2022
    12. Relative Efficacy of Minoxidil and the 5-Alpha Reductase Inhibitors in Androgenetic Alopecia Treatment of Male Patients JAMA Dermatology · 2022
    13. Long-Term Effectiveness and Safety of Dutasteride Versus Finasteride in Patients With Male Androgenic Alopecia in South Korea: A Multicentre Chart Review Study Annals of Dermatology · 2022
    14. Treatment Options for Androgenetic Alopecia: Efficacy, Side Effects, Compliance, Financial Considerations, and Ethics Journal of Cosmetic Dermatology · 2021
    15. Efficacy and Safety of Topical Finasteride Spray Solution for Male Androgenetic Alopecia: A Phase III, Randomized, Controlled Clinical Trial Journal of The European Academy of Dermatology and Venereology · 2021
    16. Transcriptome Analysis Reveals an Inhibitory Effect of Dihydrotestosterone-Treated 2D- and 3D-Cultured Dermal Papilla Cells on Hair Follicle Growth Frontiers in Cell and Developmental Biology · 2021
    17. Scalp Application of Antioxidants Improves Scalp Condition and Reduces Hair Shedding in a 24-Week Randomized, Double-Blind, Placebo-Controlled Clinical Trial International Journal of Cosmetic Science · 2021
    18. Topical Finasteride Dose Evaluation for Treatment of Androgenetic Alopecia Using Computer Simulations Annales pharmaceutiques françaises · 2021
    19. Treatment of Androgenetic Alopecia with 5-Aminolevulinic Acid Photodynamic Therapy: A Randomized, Placebo-Controlled, Split-Scalp Study of Efficacy and Safety Photodiagnosis and Photodynamic Therapy · 2021
    20. Finasteride for Hair Loss: A Review Journal of Dermatological Treatment · 2021
    21. Health-Related Quality of Life, Depression, and Self-Esteem in Patients With Androgenetic Alopecia JAMA Dermatology · 2021
    22. Efficacy of Cetirizine 1% Versus Minoxidil 5% Topical Solution in the Treatment of Male Alopecia: A Randomized, Single-Blind Controlled Study Journal of Pharmacy and Pharmaceutical Sciences · 2021
    23. Dihydrotestosterone-Induced Hair Regrowth Inhibition by Activating Androgen Receptor in C57BL6 Mice Simulates Androgenetic Alopecia Biomedicine & Pharmacotherapy · 2021
    24. A Novel Topical Combination of Minoxidil and Spironolactone for Androgenetic Alopecia: Clinical, Histopathological, and Physicochemical Study Dermatologic Therapy · 2020
    25. Intradermal Injections With 0.5% Minoxidil for the Treatment of Female Androgenetic Alopecia: A Randomized, Placebo-Controlled Trial Dermatologic Therapy · 2020
    26. Combination Therapy with Topical Minoxidil and Nano-Microneedle-Assisted Fibroblast Growth Factor for Male Androgenetic Alopecia: A Randomized Controlled Trial in Chinese Patients Chinese Medical Journal · 2020
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    35. A Randomized, Double-Blind Controlled Study of the Efficacy and Safety of Topical Solution of 0.25% Finasteride Admixed with 3% Minoxidil vs. 3% Minoxidil Solution in the Treatment of Male Androgenetic Alopecia Journal of The European Academy of Dermatology and Venereology · 2018
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    37. Androgenetic Alopecia: A Review Endocrine · 2017
    38. Superiority of Dutasteride Over Finasteride in Hair Regrowth and Reversal of Miniaturization in Men With Androgenetic Alopecia: A Randomized Controlled Open-Label, Evaluator-Blinded Study Indian Journal of Dermatology, Venereology and Leprology · 2016
    39. Long-Term Safety and Efficacy of Dutasteride in the Treatment of Male Patients with Androgenetic Alopecia Journal of Dermatology · 2016
    40. Effects of a Novel Finasteride 0.25% Topical Solution on Scalp and Serum Dihydrotestosterone in Healthy Men with Androgenetic Alopecia International Journal of Clinical Pharmacology and Therapeutics · 2015
    41. Combined Treatment with Oral Finasteride and Topical Minoxidil in Male Androgenetic Alopecia: A Randomized and Comparative Study in Chinese Patients Dermatologic Therapy · 2015
    42. Topical Formulations Containing Finasteride: In Vitro Permeation/Penetration Study and In Vivo Pharmacokinetics in Hairless Rat Journal of Pharmaceutical Sciences · 2014
    43. Topical Formulations Containing Finasteride: Determination of Finasteride Penetration into Hair Follicles Using the Differential Stripping Technique Journal of Pharmaceutical Sciences · 2014
    44. A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2002
    45. Allergic Contact Dermatitis to Topical Minoxidil Solution: Etiology and Treatment Journal of The American Academy of Dermatology · 2002
    46. Minoxidil Stimulates Mouse Vibrissae Follicles in Organ Culture Journal of Investigative Dermatology · 1989

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    1. Faculty Opinions Recommendation of Topical Finasteride for the Treatment of Male Androgenetic Alopecia and Female Pattern Hair Loss: A Review of the Current Literature Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2021
    2. Finasteride and Its Potential for the Treatment of Female Pattern Hair Loss: Evidence to Date Drug Design Development and Therapy · 2020
    3. Side Effects Related to 5 Alpha-Reductase Inhibitor Treatment of Hair Loss in Women: A Review PubMed · 2016
    4. Finasteride in the Treatment of Female Androgenic Alopecia PharmaTutor · 2014
    5. Long-Term Treatment with Finasteride 1 mg Decreases the Likelihood of Developing Further Visible Hair Loss in Men with Androgenetic Alopecia PubMed · 2008
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    7. Hair Loss in Women with Hyperandrogenism: Four Cases Responding to Finasteride Journal of The American Academy of Dermatology · 2002
    8. Advances in the Treatment of Male Androgenetic Alopecia: A Brief Review of Finasteride Studies PubMed · 2001
    9. Finasteride in the Treatment of Men with Frontal Male Pattern Hair Loss Journal of The American Academy of Dermatology · 1999
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