Treatment of Androgenetic Alopecia with 5-Aminolevulinic Acid Photodynamic Therapy: A Randomized, Placebo-Controlled, Split-Scalp Study of Efficacy and Safety

August 2021 in “ Photodiagnosis and Photodynamic Therapy ”

Zhi Cao, Xiaojing Liu, Linglin Zhang, Yunfeng Zhang, Zhongxia Zhou, Guolong Zhang, Peiru Wang, Wei-Yi Hu, Xiu-Li Wang

androgenetic alopecia 5-aminolevulinic acid photodynamic therapy ALA-PDT red-light therapy hair density sebum secretion edema AGA ALA PDT

Studysummary In this study, 5-aminolevulinic acid photodynamic therapy did not improve hair growth in patients with androgenetic alopecia but was safe and slightly reduced scalp sebum secretion.

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research Low-Level Light Therapy Using a Helmet-Type Device for the Treatment of Androgenetic Alopecia

8 citations , July 2020 in “Medicine”

In this study, low-level light therapy using a new helmet-type device significantly increased hair density and thickness in patients with androgenetic alopecia, showing no adverse events or side effects, suggesting it may be a safe and effective treatment option for both sexes.

Combination of Photodynamic Therapy with 5-Aminolaevulinic Acid and Microneedling in the Treatment of Alopecia Areata Resistant to Conventional Therapies: Our Experience with 41 Patients

research Combination of Photodynamic Therapy with 5-Aminolaevulinic Acid and Microneedling in the Treatment of Alopecia Areata Resistant to Conventional Therapies: Our Experience with 41 Patients

14 citations , August 2019 in “Clinical and Experimental Dermatology”

This study suggests that combining microneedling with ALA-photodynamic therapy may be a promising treatment option for moderate to severe alopecia areata, achieving significant hair regrowth in some patients.

The Psychosocial Burden of Alopecia Areata and Androgenetic Alopecia: A Cross-Sectional Multicentre Study Among Dermatological Outpatients in 13 European Countries

research The Psychosocial Burden of Alopecia Areata and Androgenetic Alopecia: A Cross-Sectional Multicentre Study Among Dermatological Outpatients in 13 European Countries

46 citations , August 2019 in “Journal of the European Academy of Dermatology and Venereology”

This study found that patients with alopecia areata reported worse quality of life and higher anxiety and depression levels compared to those with androgenetic alopecia and healthy controls.

research Autologous Cellular Method Using Micrografts of Human Adipose Tissue Derived Follicle Stem Cells in Androgenic Alopecia

88 citations , July 2019 in “International Journal of Molecular Sciences”

In this study of patients with Androgenic Alopecia, micro-grafts containing HD-AFSCs resulted in significantly improved hair density and follicle count over 11 months compared to a saline solution, suggesting a potential alternative therapy for hair regrowth.

Low-Level Laser Therapy for the Treatment of Androgenetic Alopecia in Thai Men and Women: A 24-Week, Randomized, Double-Blind, Sham Device-Controlled Trial

research Low-Level Laser Therapy for the Treatment of Androgenetic Alopecia in Thai Men and Women: A 24-Week, Randomized, Double-Blind, Sham Device-Controlled Trial

45 citations , December 2018 in “Lasers in Medical Science”

In a 24-week randomized trial, this study found that the RAMACAP laser helmet significantly increased hair density and diameter in androgenetic alopecia patients compared to a sham device, although limitations included a small sample size and potential issues with the control used.

research Guidelines for the Diagnosis and Treatment of Male-Pattern and Female-Pattern Hair Loss, 2017 Version

36 citations , June 2018 in “Journal of Dermatology”

This article updates Japanese guidelines for diagnosing and treating male and female-pattern hair loss, recommending specific drugs and therapies while advising against certain treatments for female-pattern hair loss.

research Low-Level Laser Therapy for the Treatment of Androgenic Alopecia: A Review

41 citations , December 2017 in “Lasers in Medical Science”

This study found that low-level laser therapy may significantly improve androgenic alopecia in both men and women, either alone or alongside treatments like minoxidil and finasteride.

research Systemic Photodynamic Therapy in Folliculitis Decalvans

14 citations , September 2017 in “Clinical and Experimental Dermatology”

In this report, a 26-year-old man with folliculitis decalvans unresponsive to standard treatments experienced significant disease clearance after 25 months of systemic photodynamic therapy, marking the first documented use of this therapy for this condition.

research Platelet-Rich Plasma for Treatment of Non-Scarring Hair Loss: Systematic Review of Literature

25 citations , March 2017 in “Journal of Dermatological Treatment”

This review found that the current evidence on using platelet rich plasma to treat non-cicatricial alopecia, such as androgenetic alopecia and alopecia areata, is of low quality and yields controversial results.

A Randomized, Active- and Placebo-Controlled Study of the Efficacy and Safety of Different Doses of Dutasteride Versus Placebo and Finasteride in the Treatment of Male Subjects with Androgenetic Alopecia

research A Randomized, Active- and Placebo-Controlled Study of the Efficacy and Safety of Different Doses of Dutasteride Versus Placebo and Finasteride in the Treatment of Male Subjects with Androgenetic Alopecia

97 citations , January 2014 in “Journal of The American Academy of Dermatology”

This study found that dutasteride increased hair growth and restoration in men with androgenetic alopecia more effectively than finasteride and was well tolerated over 24 weeks.

research Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia

205 citations , March 2012 in “Science Translational Medicine”

PGD2 stops hair growth and is higher in bald men with AGA.

Photodynamic Therapy with Methyl 5-Aminolevulinate Acid Might Be Ineffective in Recalcitrant Alopecia Totalis Regardless of Using a Microneedle Roller to Increase Skin Penetration

research Photodynamic Therapy with Methyl 5-Aminolevulinate Acid Might Be Ineffective in Recalcitrant Alopecia Totalis Regardless of Using a Microneedle Roller to Increase Skin Penetration

27 citations , May 2010 in “Dermatologic surgery”

This study found that photodynamic therapy with methyl 5-aminolevulinic acid was ineffective for treating alopecia totalis, even with microneedle rolling to enhance drug delivery.