Topical Finasteride Dose Evaluation for Treatment of Androgenetic Alopecia Using Computer Simulations

    August 2021 in “ Annales pharmaceutiques françaises ”
    D.P. Todeschini, I.C. Pedro Martinez, M. Dutra Duque
    Studysummary This study used computer simulations to evaluate the absorption of oral and topical finasteride for treating androgenetic alopecia, finding that topical applications resulted in lower plasma concentrations, suggesting potential viability as a treatment option.
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    Research cited in this study 9

    1. Effects of a Novel Finasteride 0.25% Topical Solution on Scalp and Serum Dihydrotestosterone in Healthy Men with Androgenetic Alopecia International Journal of Clinical Pharmacology and Therapeutics · 2015
    2. Finasteride Quantification in Human Plasma by High-Performance Liquid Chromatography Coupled to Electrospray Ionization Tandem Mass Spectrometry: Application to a Comparative Pharmacokinetics Study Drug research · 2015
    3. Quality Evaluation of the Finasteride Polymorphic Forms I and II in Capsules Journal of Pharmaceutical and Biomedical Analysis · 2014
    4. A Novel Finasteride 0.25% Topical Solution for Androgenetic Alopecia: Pharmacokinetics and Effects on Plasma Androgen Levels in Healthy Male Volunteers International Journal of Clinical Pharmacology and Therapeutics · 2014
    5. Finasteride: Its Impact on Sexual Function and Prostate Cancer Journal of Cutaneous and Aesthetic Surgery · 2009
    6. Medical Treatments for Male and Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2008
    7. A New Look at the 5-Alpha-Reductase Inhibitor Finasteride Cns Drug Reviews · 2006
    8. Possible Mechanisms of Miniaturization During Androgenetic Alopecia or Pattern Hair Loss Journal of The American Academy of Dermatology · 2001
    9. Fortnightly Review: Male Pattern Androgenetic Alopecia BMJ · 1998