Topical Finasteride Dose Evaluation for Treatment of Androgenetic Alopecia Using Computer Simulations
August 2021
in “
Annales pharmaceutiques françaises
”
TLDR Topical finasteride at 0.25% is effective and has fewer side effects than oral finasteride for hair loss.
The study used computer simulations with GastroPlus® software to evaluate the absorption of finasteride for treating androgenetic alopecia via oral and topical routes. The simulations showed that topical finasteride at 0.25% concentration had a good correlation with literature data (R2=0.908) and low systemic absorption (Cmax=0.04325 ng/mL), suggesting it as a potential treatment with fewer systemic side effects compared to oral administration. Simulations for 0.1% and 1% concentrations also indicated low plasma levels, supporting the efficacy and safety of topical finasteride for hair loss treatment.
