Quality Evaluation of the Finasteride Polymorphic Forms I and II in Capsules

    February 2015 in “ Journal of Pharmaceutical and Biomedical Analysis ”
    Lucélia Magalhães da Silva, Cristina Martiniano Montanari, Olimpia Maria Martins Santos, Edith Cristina Laignier Cazedey, Marilene Lopes Ângelo, Magali Benjamim Araújo
    Image of study
    TLDR Finasteride's polymorphic form affects capsule quality and drug effect, requiring strict control.
    The study evaluated the quality and stability of Finasteride polymorphic forms I and II in capsules. The study found that the use of a polymorphic form other than the one used during the formulation development process will significantly alter the dissolution properties of FNS capsules, which can alter the expected effect of this drug. Therefore, the FNS polymorphic form must be strictly controlled in the raw material by using the techniques presented in this paper (PXRD, FTIR, and DSC). The study also developed and validated a new method for evaluating the quality of Finasteride in capsules.
    Discuss this study in the Community →

    Research cited in this study

    8 / 8 results

    Related Community Posts Join

    6 / 1000+ results

      community GT-20029 should be much more superior than finasteride

      in Research/Science  45 upvotes 6 months ago
      GT-20029 is discussed as a potential hair loss treatment, with concerns about its safety and systemic absorption compared to finasteride. Users express skepticism about its effectiveness and safety, noting that it may not surpass existing treatments like finasteride and minoxidil.

      community 8-9 Month Update. 24M Korean Diffuse Thinner

      in Progress Pictures  311 upvotes 1 year ago
      The conversation discusses a 24-year-old Korean man's progress with hair loss treatments over 8-9 months, with specific treatments not mentioned due to redacted information. Users are commenting on the effectiveness and inquiring if Asians have better results with hair loss treatments.

      community Creatine is the opposite of minoxidil !

      in Research/Science  323 upvotes 1 week ago
      Creatine may counteract minoxidil's hair growth effects by closing potassium ATP channels, potentially leading to hair loss in predisposed individuals. Despite anecdotal reports, there is no conclusive evidence linking creatine to hair loss.

      community Why does it seem everyone favors finasteride over dutasteride?

      in Female  62 upvotes 1 year ago
      The conversation discusses preferences for hair loss treatments, specifically finasteride over dutasteride. Users share personal experiences, cost considerations, FDA approval status, and potential side effects, with some switching between treatments to find what works best for them.

      community Maintaining hair until Breezula without Fin

      in Treatment  6 upvotes 5 years ago
      A 21-year-old male experienced side effects from topical finasteride and is seeking alternative treatments to maintain hair until Breezula is available. He is considering using minoxidil, Nizoral, micro-needling, and vitamin D supplementation, and may try CB or RU58841 if necessary.

      community How to reduce scalp DHT as much as possible?

      in Finasteride/Dutasteride  16 upvotes 2 weeks ago
      The conversation discusses reducing scalp DHT to prevent hair loss, with a focus on using dutasteride, finasteride, and other treatments like RU58841 and minoxidil. It highlights the challenges of managing hair loss while on high testosterone levels, suggesting that dutasteride may be more effective than finasteride in such cases.

    Related Research

    3 / 3 results