Physicochemical Characterization of Finasteride: PEG 6000 and Finasteride: Kollidon K25 Solid Dispersions, and Finasteride: Beta-Cyclodextrin Inclusion Complexes

    December 2010 in “ Journal of Inclusion Phenomena and Macrocyclic Chemistry ”
    Hugo F. D. Almeida, Helena Marques
    Image of study
    TLDR Finasteride's solubility and bioavailability improved by forming solid dispersions and inclusion complexes.
    This study investigated the formation of solid dispersions and inclusion complexes of finasteride to improve its solubility and bioavailability. The results showed that solid dispersions with PEG 6000 and Kollidon K25, and inclusion complexes with β-cyclodextrin, increased finasteride dissolution rate. The DSC thermograms revealed the transformation of finasteride into the amorphous state in these formulations, and the IR spectra demonstrated molecular interaction.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community What is worth dissolving in topical minoxidil solution?

      in Treatment  3 upvotes 1 year ago
      Switching from minoxidil foam to topical solution and considering adding caffeine, melatonin, or cetirizine. Currently using 2.5mg oral minoxidil and 1mg oral finasteride, planning to ask for 0.5mg oral dutasteride and 5mg oral minoxidil.

      community Topical finasteride carrier vehicle

      in Finasteride/Dutasteride  1 upvotes 6 months ago
      The user is using a topical solution containing 1% finasteride and 5% minoxidil for hair loss, with water, glycerin, and PEG-40 hydrogenated castor oil as carrier agents. They are questioning if these ingredients are effective carriers after using the solution for three months.

      community 2 months of RU after 2 years of fin and OM ED

      in Progress Pictures  53 upvotes 2 years ago
      The user was using 1mg finasteride daily and oral minoxidil 2.5mg daily for two years, then added RU58841 to their routine two months ago and is asking for opinions on any changes in hair growth. They provided progress pictures without dermarolling and maintained consistent lighting for comparison.

      community Can I mix minoxidil with Alpecin Caffeine Liquid?

      in Minoxidil 1 year ago
      A user is considering mixing 5% topical minoxidil with Alpecin Caffeine Liquid to enhance its effect, while also using oral finasteride. They seek feedback on potential efficacy loss and downsides of this mixture.

    Similar Research

    5 / 1000+ results