Physicochemical Characterization of Finasteride: PEG 6000 and Finasteride: Kollidon K25 Solid Dispersions, and Finasteride: Beta-Cyclodextrin Inclusion Complexes

    December 2010 in “ Journal of Inclusion Phenomena and Macrocyclic Chemistry ”
    Hugo F. D. Almeida, Helena Marques
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    TLDR Finasteride's solubility and bioavailability improved by forming solid dispersions and inclusion complexes.
    This study investigated the formation of solid dispersions and inclusion complexes of finasteride to improve its solubility and bioavailability. The results showed that solid dispersions with PEG 6000 and Kollidon K25, and inclusion complexes with β-cyclodextrin, increased finasteride dissolution rate. The DSC thermograms revealed the transformation of finasteride into the amorphous state in these formulations, and the IR spectra demonstrated molecular interaction.
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