Thermodynamic Modeling of the Gas-Antisolvent Process for Precipitation of Finasteride

The research paper developed a thermodynamic model for the Gas-Antisolvent (GAS) process to precipitate Finasteride, a drug used for hair growth in men with mild to moderate androgenic alopecia. The study used the Peng-Robinson equation of state and a fugacity expression to evaluate the fluid and solid phases respectively. The GAS operating conditions were optimized to produce particles without requiring many experiments. The lowest pressures for the ternary system at 308, 318, 328, and 338 K were 7.49, 8.13, 8.51, and 9.03 MPa, respectively, at which the precipitation of the dissolved finasteride occurred. The study concluded that the GAS process can be effectively modeled and optimized for the precipitation of Finasteride.