Synthesis and Evaluation of Finasteride-Loaded HPMC-Based Nanogels for Transdermal Delivery: A Versatile Nanoscopic Platform

January 2022 in “ BioMed Research International ”

Aousaf Ahmad, Mahmood Ahmad, Muhammad Usman Minhas, Muhammad Sarfraz, Muhammad Sohail, Kifayat Ullah Khan, Sana Tanveer, Shakeel Ijaz

finasteride HPMC-based nanogels transdermal delivery free radical solution polymerization drug absorption bioavailability skin permeation drug encapsulation ex vivo skin permeation studies toxicity studies biocompatible transdermal delivery system Propecia nanogels skin absorption drug delivery

Studysummary This study found that newly developed nanogels for transdermal delivery of finasteride were stable, showed excellent drug permeation through the skin, and ensured biocompatibility without causing irritation or toxicity.

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The study developed finasteride-loaded HPMC-based nanogels for transdermal delivery to improve drug absorption and bioavailability. The nanogels were synthesized using a free radical solution polymerization method and characterized through various tests, showing high yield (≈91%), efficient drug release at pH 5.5 and 7.4, and good skin permeation without irritation or toxicity. Characterization techniques confirmed their stability, homogeneity, and successful drug encapsulation. Ex vivo skin permeation studies and toxicity studies on rabbits indicated effective drug delivery and no significant adverse effects. The findings suggest these nanogels are a stable, effective, and biocompatible transdermal delivery system for finasteride, potentially enhancing patient compliance for long-term therapy. Future in vivo studies on humans are recommended.

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