TLDR Finasteride-loaded nanogels are effective, safe, and improve drug absorption through the skin.
The study developed finasteride-loaded HPMC-based nanogels for transdermal delivery to improve drug absorption and bioavailability. The nanogels were synthesized using a free radical solution polymerization method and characterized through various tests, showing high yield (≈91%), efficient drug release at pH 5.5 and 7.4, and good skin permeation without irritation or toxicity. Characterization techniques confirmed their stability, homogeneity, and successful drug encapsulation. Ex vivo skin permeation studies and toxicity studies on rabbits indicated effective drug delivery and no significant adverse effects. The findings suggest these nanogels are a stable, effective, and biocompatible transdermal delivery system for finasteride, potentially enhancing patient compliance for long-term therapy. Future in vivo studies on humans are recommended.
23 citations,
June 2017 in “Drug Design Development and Therapy” Cyclodextrins improve finasteride's solubility and bioavailability for hair loss treatment.
28 citations,
February 2016 in “International Journal of Nanomedicine” Finasteride capsules with nanoparticles improve drug delivery, solubility, stability, and effectiveness.
39 citations,
November 2015 in “Nanomedicine” Improved Finasteride delivery for hair loss treatment.
51 citations,
October 2012 in “International Journal of Immunopathology and Pharmacology” Finasteride works better than Serenoa repens for male hair loss.
21 citations,
October 2009 in “European Journal of Pharmaceutical Sciences” Three new finasteride solvates found, change forms under different drying conditions.
61 citations,
May 2007 in “Journal of Pharmaceutical Sciences” Different forms of hair loss drug can improve effectiveness.
50 citations,
May 2000 in “Fertility and Sterility” Flutamide reduces hair growth better but has more side effects.
1054 citations,
February 1998 in “The New England Journal of Medicine” Finasteride reduces urinary issues and surgery need in men with enlarged prostates by over 50%.
96 citations,
September 2021 in “International Journal of Molecular Sciences” Chitosan, a natural substance, can be used to create tiny particles that effectively deliver various types of drugs, but more work is needed to improve stability and control of drug release.
1 citations,
August 2022 in “BioMed Research International” Chitosan-decorated nanoparticles can improve skin delivery and reduce side effects of finasteride.
March 2024 in “International journal of pharmaceutics. X” Spanlastic-laden nanogel could be a better way to deliver hair growth medication through the skin for treating hair loss.
1 citations,
January 2024 in “BioMed research international” 
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January 2017 in “Journal of Nanomedicine & Nanotechnology” Nanoemulgel could be a promising new treatment for hair loss.
