Synthesis and Evaluation of Finasteride-Loaded HPMC-Based Nanogels for Transdermal Delivery: A Versatile Nanoscopic Platform

January 2022 in “ BioMed Research International ”

Aousaf Ahmad, Mahmood Ahmad, Muhammad Usman Minhas, Muhammad Sarfraz, Muhammad Sohail, Kifayat Ullah Khan, Sana Tanveer, Shakeel Ijaz

finasteride HPMC-based nanogels transdermal delivery free radical solution polymerization drug absorption bioavailability skin permeation drug encapsulation ex vivo skin permeation studies toxicity studies biocompatible transdermal delivery system Propecia nanogels skin absorption drug delivery

Studysummary This study found that newly developed nanogels for transdermal delivery of finasteride were stable, showed excellent drug permeation through the skin, and ensured biocompatibility without causing irritation or toxicity.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on downloads.hindawi.com →

Discuss this study in the Community →

Research cited in this study

8 / 8 results

Experimental, Molecular Docking Investigations and Bioavailability Study on the Inclusion Complexes of Finasteride and Cyclodextrins

research Experimental, Molecular Docking Investigations and Bioavailability Study on the Inclusion Complexes of Finasteride and Cyclodextrins

23 citations , June 2017 in “Drug Design Development and Therapy”

This study found that the dimethyl-β-cyclodextrin inclusion system significantly improved the solubility and bioavailability of finasteride compared to the drug alone, enhancing its absorption rate.

Preparation of Finasteride Capsules-Loaded Drug Nanoparticles: Formulation, Optimization, In Vitro, and Pharmacokinetic Evaluation

research Preparation of Finasteride Capsules-Loaded Drug Nanoparticles: Formulation, Optimization, In Vitro, and Pharmacokinetic Evaluation

28 citations , February 2016 in “International Journal of Nanomedicine”

This study found that freeze-dried finasteride nanoparticles improved the stability, solubility, and in vitro dissolution of the drug, indicating potential benefits for poorly water-soluble drugs.

Self-Microemulsifying Systems of Finasteride with Enhanced Oral Bioavailability: Multivariate Statistical Evaluation, Characterization, Spray-Drying and In Vivo Studies in Human Volunteers

research Self-Microemulsifying Systems of Finasteride with Enhanced Oral Bioavailability: Multivariate Statistical Evaluation, Characterization, Spray-Drying and In Vivo Studies in Human Volunteers

39 citations , November 2015 in “Nanomedicine”

This study found that the developed Finasteride-loaded SMEDDS improved the relative bioavailability of the drug compared to a commercial tablet, offering a promising oral delivery system for glucosteroid analogs.

research Comparative Effectiveness of Finasteride vs Serenoa Repens in Male Androgenetic Alopecia: A Two-Year Study

51 citations , October 2012 in “International Journal of Immunopathology and Pharmacology”

In this study, 68% of patients treated with finasteride showed improved hair growth in male androgenetic alopecia, compared to 38% with Serenoa repens, indicating finasteride's superior efficacy.

research Three Isostructural Solvates of Finasteride and Their Solid-State Characterization

21 citations , October 2009 in “European Journal of Pharmaceutical Sciences”

This study found that drying finasteride solvates at 85 °C for one day produced a metastable anhydrous form.

research Structural Study of Polymorphs and Solvates of Finasteride

61 citations , April 2007 in “Journal of Pharmaceutical Sciences”

This study reported new crystallographic structures and polymorphs of finasteride, including several solvates with distinct X-ray diffraction patterns and thermally characterized properties.

research A Prospective, Randomized Trial Comparing Flutamide (250 mg/d) and Finasteride (5 mg/d) in the Treatment of Hirsutism

50 citations , May 2000 in “Fertility and Sterility”

This study found that flutamide was more effective than finasteride in reducing hair growth in women with hirsutism over a one-year period.

The Effect of Finasteride on the Risk of Acute Urinary Retention and the Need for Surgical Treatment Among Men with Benign Prostatic Hyperplasia

research The Effect of Finasteride on the Risk of Acute Urinary Retention and the Need for Surgical Treatment Among Men with Benign Prostatic Hyperplasia

1054 citations , February 1998 in “The New England Journal of Medicine”

In this study, men with benign prostatic hyperplasia who took finasteride for four years experienced reduced urinary symptoms, fewer surgeries, less acute urinary retention, increased urinary flow rates, and decreased prostate volume.