Three Isostructural Solvates of Finasteride and Their Solid-State Characterization
October 2009
in “
European Journal of Pharmaceutical Sciences
”
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Studysummary This study found that drying finasteride solvates at 85 °C for one day produced a metastable anhydrous form. Our plain-language summary of this paper — not a Tressless recommendation.
The paper discusses the solid-state characterization of three new solvates of finasteride, a drug used to treat hair loss. The three solvates were found to be isostructural and hemi-hydrate/channel solvates. The study also investigated the behavior of the solvates under ambient and elevated temperature vacuum drying. The results showed that vacuum drying at ambient temperature gave rise to unique solvated materials of two of the solvates, while further vacuum drying at 85°C resulted in conversion to Form II of finasteride for all three solvates. The study highlights the potential challenges in maintaining a 'selected' form throughout the development process and the possibility for form changes upon desolvation/dehydration.
