Three Isostructural Solvates of Finasteride and Their Solid-State Characterization

    October 2009 in “ European Journal of Pharmaceutical Sciences ”
    Nate Schultheiss, Jared P. Smit, Jason A. Hanko
    Image of study
    TLDR Three new finasteride solvates found, change forms under different drying conditions.
    The paper discusses the solid-state characterization of three new solvates of finasteride, a drug used to treat hair loss. The three solvates were found to be isostructural and hemi-hydrate/channel solvates. The study also investigated the behavior of the solvates under ambient and elevated temperature vacuum drying. The results showed that vacuum drying at ambient temperature gave rise to unique solvated materials of two of the solvates, while further vacuum drying at 85°C resulted in conversion to Form II of finasteride for all three solvates. The study highlights the potential challenges in maintaining a 'selected' form throughout the development process and the possibility for form changes upon desolvation/dehydration.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 1000+ results
      Can’t tolerate fin, am I screwed?

      community Can’t tolerate fin, am I screwed?

      in Finasteride  113 upvotes 2 days ago
      The user experienced sexual side effects from a topical finasteride and minoxidil combo and stopped using it after three weeks. They plan to use foam minoxidil nightly to slow hair loss and seek alternative treatments that don't affect sexual health.

      community How to safely stop topical finasteride?

      in Finasteride  62 upvotes 4 days ago
      A user is concerned about running out of topical minoxidil and finasteride and seeks advice on safely transitioning to using minoxidil alone. They wish to avoid oral finasteride due to potential side effects and have a dermatologist appointment scheduled.

      community Is it normal that fin tingles in the mouth?

      in Finasteride  59 upvotes 1 week ago
      A user experienced a tingling sensation in their mouth after taking a cut finasteride pill, possibly due to inactive ingredients like mannitol or sodium lauryl sulfate. Tingling is not a common side effect or typical allergy sign, but monitoring for unusual reactions is advised.

      community Switching from finasteride to dutasteride.

      in Finasteride  76 upvotes 1 week ago
      The user has been taking finasteride for nearly 5 years and is now adding dutasteride to their regimen to maintain hair loss prevention. They seek advice on transitioning from finasteride to dutasteride.

      community Increased Hair Shedding After Starting Finasteride

      in Finasteride  75 upvotes 1 month ago
      The user started finasteride in January 2025 and experienced increased hair shedding by March 2025, despite initial improvements from PRP treatment. They are concerned but have read that this shedding might be a temporary phase of the finasteride treatment.

    Related Research

    1 / 1 results