A Prospective, Randomized Trial Comparing Flutamide (250 mg/d) and Finasteride (5 mg/d) in the Treatment of Hirsutism

May 2000 in “ Fertility and Sterility ”

Iptisam Ipek Muderris, Fahri Bayram, Muhammed Güven

flutamide finasteride hirsutism Propecia

Studysummary This study found that flutamide was more effective than finasteride in reducing hair growth in women with hirsutism over a one-year period.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

This study compared the effectiveness of flutamide and finasteride in treating hirsutism in women. Both drugs were effective, but flutamide was more effective than finasteride in reducing hair growth. However, flutamide had more side effects. The study suggests that the choice of drug should be based on individual patient factors.

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Research cited in this study

8 / 8 results

research Finasteride Treatment for One Year in 35 Hirsute Patients

27 citations , July 2009 in “Experimental and Clinical Endocrinology & Diabetes”

This study found that finasteride significantly improved hirsutism scores in women over 12 months and was well-tolerated with no serious side effects.

A Prospective Randomized Trial Comparing Low Dose Flutamide, Finasteride, Ketoconazole, and Cyproterone Acetate-Estrogen Regimens in the Treatment of Hirsutism

research A Prospective Randomized Trial Comparing Low Dose Flutamide, Finasteride, Ketoconazole, and Cyproterone Acetate-Estrogen Regimens in the Treatment of Hirsutism

113 citations , April 1999 in “The Journal of Clinical Endocrinology and Metabolism”

This study found that all four treatments—flutamide, finasteride, ketoconazole, and EE-CPA—significantly reduced hirsutism, but EE-CPA and flutamide appeared most effective, with varying effects on androgen levels and side-effect profiles.

research Treatment of Hirsutism by Finasteride and Flutamide in Women with Polycystic Ovary Syndrome

38 citations , January 1997 in “Gynecological Endocrinology”

This study found that both finasteride and flutamide effectively reduced hirsutism in women with polycystic ovary syndrome, decreasing the Ferriman-Gallwey score and hair diameter without significant side effects.

Outcome of Long-Term Treatment with the 5α-Reductase Inhibitor Finasteride in Idiopathic Hirsutism: Clinical and Hormonal Effects During a 1-Year Course of Therapy and 1-Year Follow-Up

research Outcome of Long-Term Treatment with the 5α-Reductase Inhibitor Finasteride in Idiopathic Hirsutism: Clinical and Hormonal Effects During a 1-Year Course of Therapy and 1-Year Follow-Up

75 citations , November 1996 in “Fertility and Sterility”

This study found that finasteride effectively reduced hirsutism in women during 12 months of treatment, with some effects persisting in the majority after stopping the medication.

research Clinical and Endocrine Effects of Finasteride, a 5α-Reductase Inhibitor, in Women with Idiopathic Hirsutism

70 citations , August 1995 in “Fertility and Sterility”

In this study, women with idiopathic hirsutism who took finasteride for 9 months experienced a significant reduction in hirsutism scores compared to those receiving a placebo, with minimal side effects.

research Flutamide in the Treatment of Hirsutism

27 citations , October 1991 in “International journal of gynaecology and obstetrics”

This study observed that flutamide treatment reduced hair growth and improved acne and seborrhea in hirsute women, with increased androstenedione levels and no side effects noted.

research The Clinical Development of a 5α-Reductase Inhibitor, Finasteride

211 citations , November 1990 in “The Journal of Steroid Biochemistry and Molecular Biology”

Finasteride effectively treats BPH, but needs more trials to understand potential.

research Biological Activity of Antiandrogens

51 citations , June 1970 in “British journal of dermatology/British journal of dermatology, Supplement”

This review discusses the biology of antiandrogens and highlights available bioassay models to predict their therapeutic effects on human skin, reporting no new clinical results.