A Prospective, Randomized Trial Comparing Flutamide (250 mg/d) and Finasteride (5 mg/d) in the Treatment of Hirsutism

May 2000 in “ Fertility and Sterility ”

Iptisam Ipek Muderris, Fahri Bayram, Muhammed Güven

flutamide finasteride hirsutism Propecia

TLDR Flutamide reduces hair growth better but has more side effects.

This study compared the effectiveness of flutamide and finasteride in treating hirsutism in women. Both drugs were effective, but flutamide was more effective than finasteride in reducing hair growth. However, flutamide had more side effects. The study suggests that the choice of drug should be based on individual patient factors.

View this study on fertstert.org →

Discuss this study in the Community →

Research cited in this study

8 / 8 results

research Finasteride Treatment for One Year in 35 Hirsute Patients

27 citations, July 2009 in “Experimental and Clinical Endocrinology & Diabetes”

Finasteride safely reduces excessive hair growth in women.

A Prospective Randomized Trial Comparing Low Dose Flutamide, Finasteride, Ketoconazole, and Cyproterone Acetate-Estrogen Regimens in the Treatment of Hirsutism

research A Prospective Randomized Trial Comparing Low Dose Flutamide, Finasteride, Ketoconazole, and Cyproterone Acetate-Estrogen Regimens in the Treatment of Hirsutism

113 citations, April 1999 in “The Journal of Clinical Endocrinology and Metabolism”

Cyproterone acetate-estrogen most effective for hirsutism, but consider side effects and patient needs.

research Treatment of Hirsutism by Finasteride and Flutamide in Women with Polycystic Ovary Syndrome

38 citations, January 1997 in “Gynecological Endocrinology”

Finasteride and flutamide effectively reduce hirsutism in PCOS women, with flutamide also lowering hormone levels.

Outcome of Long-Term Treatment with the 5α-Reductase Inhibitor Finasteride in Idiopathic Hirsutism: Clinical and Hormonal Effects During a 1-Year Course of Therapy and 1-Year Follow-Up

research Outcome of Long-Term Treatment with the 5α-Reductase Inhibitor Finasteride in Idiopathic Hirsutism: Clinical and Hormonal Effects During a 1-Year Course of Therapy and 1-Year Follow-Up

75 citations, November 1996 in “Fertility and Sterility”

Finasteride effectively reduces hair growth in women with idiopathic hirsutism, but requires careful contraception during treatment.

research Clinical and Endocrine Effects of Finasteride, a 5α-Reductase Inhibitor, in Women with Idiopathic Hirsutism

70 citations, August 1995 in “Fertility and Sterility”

Finasteride reduces hairiness and androgen levels in women with unexplained excessive hair growth.

research Flutamide in the Treatment of Hirsutism

27 citations, October 1991 in “International journal of gynaecology and obstetrics”

Flutamide effectively reduces hair growth in women with hirsutism and improves acne and seborrhea without side effects.

research The Clinical Development of a 5α-Reductase Inhibitor, Finasteride

211 citations, November 1990 in “The Journal of Steroid Biochemistry and Molecular Biology”

Finasteride effectively treats BPH, but needs more trials to understand potential.

research Biological Activity of Antiandrogens

51 citations, June 1970 in “British journal of dermatology/British journal of dermatology, Supplement”

Antiandrogens may help treat conditions like excessive hair growth, prostate tumors, male baldness, and acne by blocking male hormone effects.

Related Research

5 / 5 results

research A Comparison Between Finasteride, Flutamide, and Finasteride Plus Flutamide Combination in the Treatment of Hirsutism

18 citations, January 2009 in “Journal of Endocrinological Investigation”

Flutamide works better than finasteride for hirsutism, and combining both is slightly better but not much.