A Comparison Between Finasteride, Flutamide, and Finasteride Plus Flutamide Combination in the Treatment of Hirsutism

January 2009 in “ Journal of Endocrinological Investigation ”

Kursad Unluhizarci, Deniz Ozel, Fatih Tanriverdi, Zuleyha Karaca, Fahrettin Kelestimur

TLDR Flutamide works better than finasteride for hirsutism, and combining both is slightly better but not much.

This study compared the effectiveness of finasteride, flutamide, and a combination of both drugs in treating hirsutism in women. The study found that flutamide was more effective than finasteride, and the combination of both drugs was not significantly better than flutamide alone but better than finasteride alone. The study suggests that the combination of finasteride and flutamide may be complementary in reducing androgenic activity in patients with hirsutism.

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11 / 11 results

research Finasteride Treatment for One Year in 35 Hirsute Patients

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Finasteride safely reduces excessive hair growth in women.

research A Detailed Investigation of Hirsutism in a Turkish Population: Idiopathic Hyperandrogenemia as a Perplexing Issue

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The main cause of excessive hair growth in Turkish women is Polycystic ovary syndrome, but in about one fifth of cases, the reason for high male hormone levels is unknown.

research A Comparison Between Spironolactone and Spironolactone Plus Finasteride in the Treatment of Hirsutism

47 citations , March 2004 in “European journal of endocrinology”

Spironolactone plus finasteride reduces hirsutism more effectively.

research Medical Treatment Regimens of Hirsutism

12 citations , January 2004 in “Reproductive biomedicine online”

Low-dose anti-androgen drugs and certain drug combinations are effective for hirsutism, and insulin sensitizers show promise, especially for those with polycystic ovarian syndrome.

research Low-Dose (2.5 mg/Day) Finasteride Treatment in Hirsutism

18 citations , October 2003 in “Gynecological Endocrinology”

Low-dose finasteride effectively reduces hirsutism without serious side-effects.

research The Evaluation and Management of Hirsutism

195 citations , May 2003 in “Obstetrics and gynecology (New York. 1953. Online)/Obstetrics and gynecology”

Most women with excess hair growth have an underlying hormonal issue, often treated with medication and hair removal methods.

research Use of Cyproterone Acetate, Finasteride, and Spironolactone to Treat Idiopathic Hirsutism

56 citations , April 2003 in “Fertility and Sterility”

All three treatments reduce hirsutism, but spironolactone works best long-term.

research Comparison of Diane 35 and Diane 35 Plus Finasteride in the Treatment of Hirsutism

63 citations , March 2001 in “Fertility and Sterility”

Diane 35 plus finasteride is more effective for treating hirsutism.

research Screening for 21-Hydroxylase-Deficient Nonclassic Adrenal Hyperplasia Among Hyperandrogenic Women: A Prospective Study

216 citations , November 1999 in “Fertility and Sterility”

Testing basal 17-HP levels is a good way to screen for nonclassic adrenal hyperplasia in women with high androgen levels.

research Comparison of Finasteride Versus Flutamide in the Treatment of Hirsutism

75 citations , October 1999 in “European journal of endocrinology”

Finasteride is a safe, effective treatment for hirsutism with fewer side effects.

research Treatment of Hirsutism: Comparisons Between Different Antiandrogens with Central and Peripheral Effects

75 citations , March 1999 in “Fertility and sterility”

Finasteride, CPA, and flutamide are all equally effective in reducing excessive hair growth in women.

4 / 4 results

research Treatment of Hyperandrogenic Alopecia in Women

June 2003 in “Obstetrical & Gynecological Survey”

Hair loss in women can be treated with hormone therapy.

research Anti-Androgens for the Treatment of Hirsutism

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Different anti-androgen medications can help treat excessive hair growth, but the right choice depends on accurate diagnosis.

research Comparison of Finasteride and Flutamide in the Treatment of Idiopathic Hirsutism

32 citations , July 1999 in “Fertility and Sterility”

Finasteride and flutamide both reduce hair growth, but finasteride has fewer side effects.

research PLASMA C19 STEROID SULPHATE LEVELS AND INDICES OF ANDROGEN BIOAVAILABILITY IN FEMALE PATTERN ANDROGENIC ALOPECIA

32 citations , January 1990 in “Clinical Endocrinology”

Women with female pattern hair loss have higher levels of certain androgens, suggesting increased androgen exposure to hair follicles.