Plasma C19 Steroid Sulfate Levels and Indices of Androgen Bioavailability in Female Pattern Androgenic Alopecia

January 1990 in “ Clinical Endocrinology ”

J. Montalto, C B Whorwood, John W. Funder, Arthur B.W. Yong, Anna C. Callan, Hywel A. Davies, James N. Connelly

TLDR Women with female pattern hair loss have higher levels of certain androgens, suggesting increased androgen exposure to hair follicles.

In a 1990 study, researchers examined androgen metabolism in premenopausal women with female pattern androgenic alopecia (AA) compared to normal controls, although the exact number of participants was not specified. They found no significant difference in dehydroepiandrosterone sulphate (DHEA-S) and total testosterone (T) levels between the two groups. However, sex hormone binding globulin (SHBG) concentrations were significantly lower, and the free androgen index (FAI), free testosterone, non-SHBG bound T, and androstenedione levels were significantly higher in the AA group. Additionally, plasma concentrations of 5-androstene-3β,17β-diol sulphate (5-ADIOL-S) and 5α-androstane-3α,17β-diol sulphate (3α-DIOL-S) were significantly elevated in women with AA. These findings suggest that 5-ADIOL-S and 3α-DIOL-S could be useful markers for AA and its treatment, indicating increased androgen availability to hair follicles in women with AA.

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Female Androgenic Alopecia: The 3 Alpha, 17 Beta-Androstanediol Glucuronide/Sex Hormone Binding Globulin Ratio as a Possible Marker for Female Pattern Baldness

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research Low Sex-Hormone Binding Globulin Levels in Young Women with Diffuse Hair Loss

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Young women with diffuse hair loss may have low SHBG levels, which could lead to more active testosterone and contribute to their hair loss.

research Classification of the Types of Androgenetic Alopecia (Common Baldness) Occurring in the Female Sex

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Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

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in Research 865 upvotes 1 year ago

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community 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that?

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Finasteride and dutasteride are discussed for hair loss, with concerns about their effects on neurosteroids and potential side effects like depression. Alternatives like topical estrogen and lifestyle changes are considered, with varying opinions on mental health and hair regrowth.

community here is why isotretinoin might cause hair loss and maybe why dupa happens.

in Research/Science 7 upvotes 2 years ago

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in Chat 6 upvotes 1 year ago

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community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

in Research 413 upvotes 10 months ago

Treating androgenic alopecia with minoxidil, finasteride, and antiandrogens, alongside exercise, cryotherapy, and natural substances to stimulate cold receptors for better hair growth. The method focuses on enhancing treatment effectiveness by considering environmental and behavioral factors and the role of cold receptors and muscle stress.

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