TLDR Finasteride capsules with nanoparticles improve drug delivery, solubility, stability, and effectiveness.
This document summarizes several studies that aimed to prepare and evaluate finasteride capsules loaded with drug nanoparticles for improved drug delivery. The studies used various techniques to optimize the formulation and processing variables, resulting in improved solubility, stability, and in vitro dissolution of the drug. The pharmacokinetic studies in animals showed that the optimized nanoparticles had a higher bioavailability compared to the non-nanosized drug. The studies suggest that the use of nanotechnology can enhance the bioavailability and efficacy of finasteride.
93 citations,
January 1996 in “Clinical Pharmacokinectics” Finasteride helps regrow hair and shrink prostate by reducing DHT, with some sexual side effects.
70 citations,
June 1993 in “Biochemistry” Finasteride slowly binds to 5-alpha-reductase, affecting enzyme stability and inhibitor potency.
1 citations,
August 2022 in “BioMed Research International” Chitosan-decorated nanoparticles can improve skin delivery and reduce side effects of finasteride.
23 citations,
March 2019 in “Environmental Chemistry Letters” Cyclodextrins improve how steroid drugs work and are used in marketed medications and environmental applications.
27 citations,
August 2018 in “Therapeutic Delivery” Nanotechnology could make hair loss treatments more effective and reduce side effects, but more research is needed before it's available.
May 2024 in “Brazilian Journal of Hair Health” Finasteride-loaded nanoparticles were successfully created for potential improved hair growth treatment.
12 citations,
March 2020 in “Journal of Bioactive and Compatible Polymers” Nanoparticles show potential for controlled release of hair loss drugs, improving treatment effectiveness.
