Unlocking Finasteride's Potential Via Carboxymethyl-Beta-Cyclodextrin Inclusion Complex For Androgenic Alopecia

    March 2025 in “ Carbohydrate Polymer Technologies and Applications ”
    Reza Allahyari, Behnam Mahdavi, Esmail Rezaei‐Seresht, Mehdi Baghayeri
    TLDR The new method improves finasteride's effectiveness for hair loss treatment.
    The study investigates the use of carboxymethyl-β-cyclodextrin (CM-β-CD) to enhance the delivery and effectiveness of finasteride for treating androgenic alopecia. By forming a CM-β-CD/Fin inclusion complex, the research improves finasteride's solubility, stability, and bioavailability, achieving a 9.36-fold increase in solubility and an encapsulation efficiency of 85%. The complex shows a favorable thermodynamic profile and is safe, maintaining high cell viability in cytotoxicity tests. The drug release study indicates an initial rapid release followed by controlled release, potentially improving therapeutic outcomes and patient compliance by reducing dosing frequency. However, regulatory challenges must be addressed for clinical application.
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      community Temporary alternative to finasteride?

      in Finasteride  87 upvotes 5 days ago
      A 23-year-old male plans to temporarily stop finasteride to donate plasma for financial reasons and seeks alternative hair loss treatments like minoxidil, ketoconazole, or RU58841 during this period. He is open to suggestions to prevent further hair loss until he can resume finasteride.

      community Sensitive liver, topical fin safe to try?

      in Finasteride  98 upvotes 1 week ago
      Topical finasteride is considered safer for the liver than oral finasteride due to less systemic absorption, but regular liver function tests are advised. The user is concerned about liver health due to a history of NAFLD and is exploring topical finasteride as a safer alternative.

      community 8 months Fin + Oral Minox - still losing some hairs, normal?

      in Finasteride  90 upvotes 1 week ago
      After 8 months of using oral Minoxidil 5mg and Finasteride 1mg, the user still experiences hair loss, particularly miniaturized hairs in the mid-scalp area, along with itching. They are concerned about losing around 40 hairs daily despite treatment.

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