Unlocking Finasteride's Potential Via Carboxymethyl-Beta-Cyclodextrin Inclusion Complex For Androgenic Alopecia

March 2025 in “ Carbohydrate Polymer Technologies and Applications ”

Reza Allahyari, Behnam Mahdavi, Esmail Rezaei‐Seresht, Mehdi Baghayeri

finasteride carboxymethyl-β-cyclodextrin androgenic alopecia CM-β-CD inclusion complex bioavailability solubility encapsulation efficiency thermodynamic profile cytotoxicity tests drug release study Propecia

TLDR The new method improves finasteride's effectiveness for hair loss treatment.

The study investigates the use of carboxymethyl-β-cyclodextrin (CM-β-CD) to enhance the delivery and effectiveness of finasteride for treating androgenic alopecia. By forming a CM-β-CD/Fin inclusion complex, the research improves finasteride's solubility, stability, and bioavailability, achieving a 9.36-fold increase in solubility and an encapsulation efficiency of 85%. The complex shows a favorable thermodynamic profile and is safe, maintaining high cell viability in cytotoxicity tests. The drug release study indicates an initial rapid release followed by controlled release, potentially improving therapeutic outcomes and patient compliance by reducing dosing frequency. However, regulatory challenges must be addressed for clinical application.

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Research cited in this study

11 / 11 results

research Topical Finasteride Dose Evaluation for Treatment of Androgenetic Alopecia Using Computer Simulations

August 2021 in “Annales pharmaceutiques françaises”

Topical finasteride at 0.25% is effective and has fewer side effects than oral finasteride for hair loss.

research Physicochemical Characterization of Finasteride Nanosystem for Enhanced Topical Delivery

10 citations, February 2021 in “International Journal of Nanomedicine”

Chitosan-decorated finasteride nanosystems improve skin retention and could be a better treatment for hair loss.

research Encapsulation of Finasteride with Native and Modified Gamma-Cyclodextrins: Extensive Characterization of the Complexes

8 citations, July 2020 in “International Journal of Pharmaceutics”

Finasteride's solubility improves with native y-CDs, enhancing hair loss treatment and reducing side effects.

research Enhancement of Dermal Delivery of Finasteride Using Microemulsion Systems

18 citations, October 2019 in “Advanced Pharmaceutical Bulletin”

Microemulsions can improve skin delivery of finasteride.

research Applications of Steroid Drugs Entrapped in Cyclodextrins

23 citations, March 2019 in “Environmental Chemistry Letters”

Cyclodextrins improve how steroid drugs work and are used in marketed medications and environmental applications.

Experimental, Molecular Docking Investigations and Bioavailability Study on the Inclusion Complexes of Finasteride and Cyclodextrins

research Experimental, Molecular Docking Investigations and Bioavailability Study on the Inclusion Complexes of Finasteride and Cyclodextrins

23 citations, June 2017 in “Drug Design Development and Therapy”

Cyclodextrins improve finasteride's solubility and bioavailability for hair loss treatment.

research Androgenetic Alopecia: A Review

153 citations, March 2017 in “Endocrine”

Male pattern baldness involves genetics, hormones, and needs better treatments.

Preparation and Evaluation of a Multimodal Minoxidil Microemulsion Versus Minoxidil Alone in the Treatment of Androgenic Alopecia of Mixed Etiology: A Pilot Study

research Preparation and Evaluation of a Multimodal Minoxidil Microemulsion Versus Minoxidil Alone in the Treatment of Androgenic Alopecia of Mixed Etiology: A Pilot Study

24 citations, May 2013 in “Drug Design Development and Therapy”

Multimodal minoxidil microemulsion is more effective in treating hair loss than minoxidil alone.

research Binary and Ternary Inclusion Complexes of Finasteride in HPβCD and Polymers: Preparation and Characterization

37 citations, April 2009 in “Bioorganic & Medicinal Chemistry”

Finasteride complexes with HPβCD and polymers improve solubility, potentially enhancing hair loss treatment.

research Androgen Dependence of Hirsutism, Acne, and Alopecia in Women

105 citations, January 2009 in “Medicine”

Hirsutism is more linked to high androgen levels than acne or hair loss, and a mix of hormonal tests is best for diagnosis; certain treatments can reduce symptoms.

research Finasteride

86 citations, July 1993 in “Drugs”

Finasteride treats enlarged prostate, shrinks it, improves urination, but may cause sexual dysfunction and isn't for women or children.

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A 20-year-old started finasteride two weeks ago for hair loss at Norwood 2 and is seeking experiences from others who began treatment at a young age. The discussion focuses on age-related experiences with finasteride.

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The user experienced bladder and prostate discomfort after taking finasteride and stopped the medication, but symptoms returned upon resuming at a lower dose. The doctor suggested trying dutasteride as an alternative.

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The conversation discusses concerns about the effectiveness of finasteride for hair loss. The user is worried about being a non-responder to the treatment.

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A user is making a homemade topical finasteride solution by dissolving crushed finasteride tablets in ethanol and PG. They are unsure if the final solution maintains the intended concentration after filtering and are considering adding more ethanol to ensure accuracy.

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research Use of Finasteride in the Treatment of Men With Androgenetic Alopecia

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Finasteride effectively improves hair growth and slows hair loss in men with male pattern baldness.