Binary and Ternary Inclusion Complexes of Finasteride in HPβCD and Polymers: Preparation and Characterization

April 2009 in “ Bioorganic & Medicinal Chemistry ”

Ana Carolina Cavazzin Asbahr, Luzia Franco, Andersson Barison, Caroline Santos Silva, Humberto Gomes Ferraz, Letícia Rodrigues

finasteride HPβCD chitosan PVP K30 inclusion complexes solubility dissolution rate drug delivery systems Propecia

TLDR Finasteride complexes with HPβCD and polymers improve solubility, potentially enhancing hair loss treatment.

This study investigated the formation of inclusion complexes of finasteride with HPβCD and various polymers to improve the solubility and dissolution rate of the drug. The study found that true binary and ternary inclusion complexes were formed, and the ternary systems with chitosan or PVP K30 had higher solubility of FIN than the binary system. The study suggests that inclusion complexes of FIN in HPβCD and polymers may have potential applications in drug delivery systems and could potentially enhance the effectiveness of finasteride in treating hair loss.

View this study on sciencedirect.com →

Discuss this study in the Community →

Research cited in this study

1 / 1 results

research Dihydrotestosterone And The Prostate: The Scientific Rationale For 5α-Reductase Inhibitors In The Treatment Of Benign Prostatic Hyperplasia

235 citations, September 2004 in “The Journal of urology/The journal of urology”

Drugs that block DHT production can effectively treat enlarged prostate and improve urinary issues with some sexual side effects.

Related Community Posts Join

6 / 1000+ results

community Can someone explain the science behind why Finasteride doesn't stop you from losing regrown hairs from minoxidil?

in Minoxidil 100 upvotes 2 weeks ago

Finasteride prevents further hair loss by blocking DHT, while minoxidil stimulates hair growth by prolonging the active phase of hair follicles. Stopping minoxidil can lead to loss of regrown hair because finasteride does not address the same growth mechanism.

community 1 year topical fin/min coupled with frontal HT

in Progress Pictures 192 upvotes 11 months ago

The user experienced significant hair improvement after one year using topical finasteride and minoxidil, combined with a hair transplant at the front. They switched from oral to topical finasteride due to side effects and are satisfied with the results, especially at the temples.

community 9months progress fin/derma pen/minoxidil

in Progress Pictures 1000 upvotes 4 years ago

A user's 9 month progress using Finasteride, Derma Pen/Roller and Minoxidil to treat hair loss. Replies in the conversation include advice on topical application of Minoxidil and Dutasteride for regrowth and hair thickness.

community New update. 16 months on finasteride, 25 year old, 1.25mg daily. The first picture is a screenshot from a video taken in February 2023, hence the quality is kinda poor.

in Progress Pictures 418 upvotes 6 months ago

A 25-year-old user shared progress pictures after 16 months of using 1.25mg daily finasteride for hair loss, reporting noticeable results around months 4-5 and some initial side effects that resolved. The user experienced thickening and slight regrowth of the hairline.

community 20yo, dutasteride and minoxidil aren’t working

in Finasteride/Dutasteride 117 upvotes 3 months ago

A 20-year-old reports worsening hair loss despite using dutasteride and minoxidil, and considers a hair transplant. Users suggest continuing treatments, trying microneedling, ketoconazole shampoo, switching to finasteride, or adding tretinoin.

community Solving Hair Loss with Research at MIT

in Research/Science 594 upvotes 2 months ago

Hair loss treatments like minoxidil, finasteride, TDM-105795, and PP405. MIT is hosting a hackathon to find innovative hair loss solutions.

Related Research

1 / 1 results

research Binary and Ternary Inclusion Complexes of Finasteride in HPβCD and Polymers: Preparation and Characterization

37 citations, April 2009 in “Bioorganic & Medicinal Chemistry”

Finasteride complexes with HPβCD and polymers improve solubility, potentially enhancing hair loss treatment.