Enhancement of Dermal Delivery of Finasteride Using Microemulsion Systems

October 2019 in “ Advanced Pharmaceutical Bulletin ”

Saeed Mohammad Soleymani, Anayatollah Salimi

finasteride microemulsions dermal delivery pseudo-ternary phase diagram physicochemical properties drug release profile flux permeability coefficient rat skin skin delivery Propecia MEs

Studysummary This study found that finasteride microemulsions significantly increased skin permeability in vitro, highlighting the potential for enhanced delivery of this drug through the skin.

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The study aimed to enhance the dermal delivery of finasteride, a drug used for treating hair loss and acne, by formulating microemulsions (MEs). The MEs were prepared using a pseudo-ternary phase diagram method and characterized for their physicochemical properties. The results showed that the mean droplet size of the MEs ranged from 5-17 nm, with a pH of 5.1-5.7 and viscosity between 86.4-209.6 cps. The drug release profile indicated that 49.510% of finasteride was released over 24 hours. The MEs significantly increased the flux and permeability coefficient of finasteride through rat skin, and the formulations remained stable with 99.9% finasteride after six months of storage. The study concluded that changes in ME composition could alter their properties and permeability, ultimately enhancing skin delivery of finasteride.

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Research cited in this study

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Preparation and Evaluation of a Multimodal Minoxidil Microemulsion Versus Minoxidil Alone in the Treatment of Androgenic Alopecia of Mixed Etiology: A Pilot Study

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This pilot study found that a multimodal minoxidil microemulsion with diclofenac and tea tree oil was more effective and safer than minoxidil alone for treating androgenic alopecia over 32 weeks.

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This study found that ethinylestradiol and high-dose cyproterone acetate significantly reduced hirsutism scores and were effective for treating acne and alopecia in women with hyperandrogenism.