Enhancement of Dermal Delivery of Finasteride Using Microemulsion Systems

    October 2019 in “ Advanced Pharmaceutical Bulletin ”
    Saeed Mohammad Soleymani, Anayatollah Salimi
    TLDR Microemulsions can improve skin delivery of finasteride.
    The study aimed to enhance the dermal delivery of finasteride, a drug used for treating hair loss and acne, by formulating microemulsions (MEs). The MEs were prepared using a pseudo-ternary phase diagram method and characterized for their physicochemical properties. The results showed that the mean droplet size of the MEs ranged from 5-17 nm, with a pH of 5.1-5.7 and viscosity between 86.4-209.6 cps. The drug release profile indicated that 49.510% of finasteride was released over 24 hours. The MEs significantly increased the flux and permeability coefficient of finasteride through rat skin, and the formulations remained stable with 99.9% finasteride after six months of storage. The study concluded that changes in ME composition could alter their properties and permeability, ultimately enhancing skin delivery of finasteride.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 1000+ results

      community Temporary alternative to finasteride?

      in Finasteride  99 upvotes 1 week ago
      A 23-year-old male plans to temporarily stop finasteride to donate plasma for financial reasons and seeks alternative hair loss treatments like minoxidil, ketoconazole, or RU58841 during this period. He is open to suggestions to prevent further hair loss until he can resume finasteride.

      community Sensitive liver, topical fin safe to try?

      in Finasteride  98 upvotes 1 week ago
      Topical finasteride is considered safer for the liver than oral finasteride due to less systemic absorption, but regular liver function tests are advised. The user is concerned about liver health due to a history of NAFLD and is exploring topical finasteride as a safer alternative.

      community 8 months Fin + Oral Minox - still losing some hairs, normal?

      in Finasteride  90 upvotes 2 weeks ago
      After 8 months of using oral Minoxidil 5mg and Finasteride 1mg, the user still experiences hair loss, particularly miniaturized hairs in the mid-scalp area, along with itching. They are concerned about losing around 40 hairs daily despite treatment.

    Related Research

    2 / 2 results