Encapsulation of Finasteride with Native and Modified Gamma-Cyclodextrins: Extensive Characterization of the Complexes

July 2020 in “ International Journal of Pharmaceutics ”

Rebeca González-Louzao, Carmen Lucas-Abellán, Horacio Pérez-Sánchez, José P. Cerón-Carrasco, José Antonio Gabaldón, Santiago López-Miranda, Maria Josefa Yáñez-Gascón, Manuel Asín-Llorca, Estrella Núñez-Delicado

finasteride γ-cyclodextrins cyclodextrins androgenic alopecia topical application Propecia

TLDR Finasteride's solubility improves with native y-CDs, enhancing hair loss treatment and reducing side effects.

The study explores the use of cyclodextrins (CDs) to increase the solubility of finasteride, a drug used to treat hair loss. The most effective CD was found to be native y-CDs, which formed stable complexes with finasteride. The study concludes that this method of obtaining FIN-y-CDs complexes in aqueous solution could be used for topical application in the treatment of androgenic alopecia, improving its therapeutic possibilities while avoiding side effects.

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