Experimental, Molecular Docking Investigations and Bioavailability Study on the Inclusion Complexes of Finasteride and Cyclodextrins

    June 2017 in “ DOAJ (DOAJ: Directory of Open Access Journals) ”
    Mady FM, Farghaly Aly U
    TLDR Combining finasteride with dimethyl-β-cyclodextrin improves its absorption and bioavailability.
    The study investigated the inclusion complexes of finasteride (FIN) with various β-cyclodextrins (β-CyDs) to enhance its solubility and bioavailability. Using differential scanning calorimetry, infrared spectroscopy, X-ray diffractometry, and dissolution studies, the researchers found that the dimethyl-β-cyclodextrin (DM-β-CyD) inclusion system provided the highest complexation efficiency. Molecular docking confirmed the suitable arrangement of FIN within the β-CyD cavity. Pharmacokinetic analysis showed that the FIN/DM-β-CyD complex had a higher absorption rate and greater area under the curve compared to FIN alone, indicating improved absorption and bioavailability.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community Hair theory Scar tissue and Verteporfin

      in Chat  25 upvotes 5 months ago
      A user suggests that deeper microneedling with Verteporfin injections might help regrow hair in areas with scar tissue, alongside a DHT blocker. Another user explains that hair loss might be due to reduced Wnt/β-Catenin signaling and suggests that treatments like Minoxidil, Finasteride, and microneedling could potentially reverse it.

      community DHT/Testosterone levels in scalp Fin VS Dut.

      in Finasteride/Dutasteride  60 upvotes 4 months ago
      Dutasteride raises scalp testosterone by 99%, which may not be ideal for those sensitive to all androgens. Some argue finasteride's balancing act might be better, while others believe dutasteride is superior for hair regrowth.

      community Trying to understand finasteride side effects and post finasteride syndrome

      in Finasteride/Dutasteride  74 upvotes 4 years ago
      The conversation discusses the side effects of finasteride, including low libido and erectile dysfunction, and the possibility of these effects being permanent, known as post-finasteride syndrome (PFS). Some users report personal experiences with PFS and debate whether the condition is real, with varying opinions on the reversibility of side effects and the role of individual biology.

      community Finasteride vs Dutasteride: The Science

      in Research/Science  168 upvotes 10 months ago
      The conversation compares Finasteride and Dutasteride for hair loss treatment, discussing their effectiveness and side effects. Users share personal results and consider combining treatments like Dutasteride with RU58841.

    Related Research

    6 / 6 results