Experimental, Molecular Docking Investigations and Bioavailability Study on the Inclusion Complexes of Finasteride and Cyclodextrins

    June 2017 in “ DOAJ (DOAJ: Directory of Open Access Journals) ”
    Mady FM, Farghaly Aly U
    TLDR Combining finasteride with dimethyl-β-cyclodextrin improves its absorption and bioavailability.
    The study investigated the inclusion complexes of finasteride (FIN) with various β-cyclodextrins (β-CyDs) to enhance its solubility and bioavailability. Using differential scanning calorimetry, infrared spectroscopy, X-ray diffractometry, and dissolution studies, the researchers found that the dimethyl-β-cyclodextrin (DM-β-CyD) inclusion system provided the highest complexation efficiency. Molecular docking confirmed the suitable arrangement of FIN within the β-CyD cavity. Pharmacokinetic analysis showed that the FIN/DM-β-CyD complex had a higher absorption rate and greater area under the curve compared to FIN alone, indicating improved absorption and bioavailability.
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