Granules of Finasteride and Cyclodextrin Obtained by Hot-Melt Extrusion to Target the Hair Follicles

This study developed granules of finasteride and cyclodextrin using hot-melt extrusion to target hair follicles for the treatment of alopecia. The granules showed improved solubility and dissolution rate compared to pure finasteride, indicating potential for follicular targeting and a promising approach for the treatment of alopecia. The study suggests that using granules of finasteride and cyclodextrin produced through hot-melt extrusion could be an effective treatment for hair loss by targeting hair follicles.