Granules of Finasteride and Cyclodextrin Obtained by Hot-Melt Extrusion to Target the Hair Follicles

June 2021 in “ Powder Technology ”

Stephania G.B. Lima, Ludmila A.G. Pinho, Livia L. Sa-Barreto, Tais Gratieri, Angel Concheiro

finasteride cyclodextrin hot-melt extrusion hair follicles alopecia solubility dissolution rate Propecia

Studysummary This study developed finasteride-containing granules using a method that improved follicular targeting for androgenic alopecia and reported potential for easy industrial production. Our plain-language summary of this paper — not a Tressless recommendation.

This study developed granules of finasteride and cyclodextrin using hot-melt extrusion to target hair follicles for the treatment of alopecia. The granules showed improved solubility and dissolution rate compared to pure finasteride, indicating potential for follicular targeting and a promising approach for the treatment of alopecia. The study suggests that using granules of finasteride and cyclodextrin produced through hot-melt extrusion could be an effective treatment for hair loss by targeting hair follicles.

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