Granules of Finasteride and Cyclodextrin Obtained by Hot-Melt Extrusion to Target the Hair Follicles

    June 2021 in “ Powder Technology ”
    Stephania G.B. Lima, Ludmila A.G. Pinho, Livia L. Sa-Barreto, Tais Gratieri, Angel Concheiro
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    TLDR Granules improve hair loss treatment by targeting follicles.
    This study developed granules of finasteride and cyclodextrin using hot-melt extrusion to target hair follicles for the treatment of alopecia. The granules showed improved solubility and dissolution rate compared to pure finasteride, indicating potential for follicular targeting and a promising approach for the treatment of alopecia. The study suggests that using granules of finasteride and cyclodextrin produced through hot-melt extrusion could be an effective treatment for hair loss by targeting hair follicles.
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