Granules of Finasteride and Cyclodextrin Obtained by Hot-Melt Extrusion to Target the Hair Follicles

June 2021 in “ Powder Technology ”

Stephania G.B. Lima, Ludmila A.G. Pinho, Livia L. Sa-Barreto, Tais Gratieri, Angel Concheiro

finasteride cyclodextrin hot-melt extrusion hair follicles alopecia solubility dissolution rate Propecia

TLDR Granules improve hair loss treatment by targeting follicles.

This study developed granules of finasteride and cyclodextrin using hot-melt extrusion to target hair follicles for the treatment of alopecia. The granules showed improved solubility and dissolution rate compared to pure finasteride, indicating potential for follicular targeting and a promising approach for the treatment of alopecia. The study suggests that using granules of finasteride and cyclodextrin produced through hot-melt extrusion could be an effective treatment for hair loss by targeting hair follicles.

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Granules of Finasteride and Cyclodextrin Obtained by Hot-Melt Extrusion to Target the Hair Follicles

Research cited in this study

research Novel Iron Oxide Nanocarriers Loading Finasteride or Dutasteride: Enhanced Skin Penetration for Topical Treatment of Alopecia

research Encapsulation of Finasteride with Native and Modified Gamma-Cyclodextrins: Extensive Characterization of the Complexes

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research Characterization of Minoxidil/Hydroxypropyl-β-Cyclodextrin Inclusion Complex in Aqueous Alginate Gel Useful for Alopecia Management: Efficacy Evaluation in Male Rats

research Experimental, Molecular Docking Investigations and Bioavailability Study on the Inclusion Complexes of Finasteride and Cyclodextrins

research Solid Effervescent Formulations as a New Approach for Topical Minoxidil Delivery

research Minoxidil Topical Treatment May Be More Efficient If Applied on Damp Scalp Compared to Dry Scalp

research Quality Evaluation of the Finasteride Polymorphic Forms I and II in Capsules

research Comprehensive Spectroscopic Characterization of Finasteride Polymorphic Forms: Does Form X Exist?

research Iontophoresis-Targeted, Follicular Delivery of Minoxidil Sulfate for the Treatment of Alopecia

research Design and In Vitro Evaluation of Finasteride-Loaded Liquid Crystalline Nanoparticles for Topical Delivery

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research Binary and Ternary Inclusion Complexes of Finasteride in HPβCD and Polymers: Preparation and Characterization

research In Vitro Percutaneous Permeation and Skin Accumulation of Finasteride Using Vesicular Ethosomal Carriers

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research Structural Study of Polymorphs and Solvates of Finasteride

research Enhancement of Follicular Delivery of Finasteride by Liposomes and Niosomes

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