Granules of Finasteride and Cyclodextrin Obtained by Hot-Melt Extrusion to Target the Hair Follicles

    June 2021 in “ Powder Technology ”
    Stephania G.B. Lima, Ludmila A.G. Pinho, Livia L. Sa-Barreto … Angel Concheiro
    Studysummary This study developed finasteride-containing granules using a method that improved follicular targeting for androgenic alopecia and reported potential for easy industrial production.
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    Research cited in this study 20

    1. Novel Iron Oxide Nanocarriers Loading Finasteride or Dutasteride: Enhanced Skin Penetration for Topical Treatment of Alopecia International Journal of Pharmaceutics · 2020
    2. Encapsulation of Finasteride with Native and Modified Gamma-Cyclodextrins: Extensive Characterization of the Complexes International Journal of Pharmaceutics · 2020
    3. Dutasteride Nanocapsules for Hair Follicle Targeting: Effect of Chitosan-Coating and Physical Stimulus International Journal of Biological Macromolecules · 2020
    4. Health Risks Associated with Long-Term Finasteride and Dutasteride Use: It's Time to Sound the Alarm The World Journal of Men's Health · 2020
    5. Mechanism of Androgenic Alopecia: Addressing Speculations Through Empirical Evidence Dermatologic Therapy · 2019
    6. Preformulation Studies of Finasteride to Design Matrix Systems for Topical Delivery Journal of Pharmaceutical and Biomedical Analysis · 2018
    7. Characterization of Minoxidil/Hydroxypropyl-β-Cyclodextrin Inclusion Complex in Aqueous Alginate Gel Useful for Alopecia Management: Efficacy Evaluation in Male Rats European Journal of Pharmaceutics and Biopharmaceutics · 2017
    8. Experimental, Molecular Docking Investigations and Bioavailability Study on the Inclusion Complexes of Finasteride and Cyclodextrins Drug Design Development and Therapy · 2017
    9. Solid Effervescent Formulations as a New Approach for Topical Minoxidil Delivery European Journal of Pharmaceutical Sciences · 2016
    10. Minoxidil Topical Treatment May Be More Efficient If Applied on Damp Scalp Compared to Dry Scalp Dermatologic Therapy · 2016
    11. Comprehensive Spectroscopic Characterization of Finasteride Polymorphic Forms: Does Form X Exist? Journal of Pharmaceutical Sciences · 2015
    12. Quality Evaluation of the Finasteride Polymorphic Forms I and II in Capsules Journal of Pharmaceutical and Biomedical Analysis · 2014
    13. Iontophoresis-Targeted, Follicular Delivery of Minoxidil Sulfate for the Treatment of Alopecia Journal of Pharmaceutical Sciences · 2013
    14. Design and In Vitro Evaluation of Finasteride-Loaded Liquid Crystalline Nanoparticles for Topical Delivery Aaps Pharmscitech · 2012
    15. Effect of Charge Carrier Lipid on Skin Penetration, Retention, and Hair Growth of Topically Applied Finasteride-Containing Liposomes Biomolecules & Therapeutics · 2011
    16. Binary and Ternary Inclusion Complexes of Finasteride in HPβCD and Polymers: Preparation and Characterization Bioorganic & Medicinal Chemistry · 2009
    17. In Vitro Percutaneous Permeation and Skin Accumulation of Finasteride Using Vesicular Ethosomal Carriers Aaps Pharmscitech · 2008
    18. Preparation of Novel Polymeric Microspheres for Controlled Release of Finasteride International Journal of Pharmaceutics · 2007
    19. Structural Study of Polymorphs and Solvates of Finasteride Journal of Pharmaceutical Sciences · 2007
    20. Enhancement of Follicular Delivery of Finasteride by Liposomes and Niosomes International Journal of Pharmaceutics · 2006