Experimental, Molecular Docking Investigations and Bioavailability Study on the Inclusion Complexes of Finasteride and Cyclodextrins

    June 2017 in “ Drug Design Development and Therapy ”
    Fatma M. Mady, Usama Farghaly Aly
    Studysummary This study found that the dimethyl-β-cyclodextrin inclusion system significantly improved the solubility and bioavailability of finasteride compared to the drug alone, enhancing its absorption rate.
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    Research cited in this study 4

    1. A Rapid, Simple, Liquid Chromatographic-Electrospray Ionization, Ion Trap Mass Spectrometry Method for the Determination of Finasteride in Human Plasma and Its Application to Pharmacokinetic Study PubMed · 2012
    2. Male Androgenetic Alopecia Expert Opinion on Pharmacotherapy · 2010
    3. Binary and Ternary Inclusion Complexes of Finasteride in HPβCD and Polymers: Preparation and Characterization Bioorganic & Medicinal Chemistry · 2009
    4. The Clinical Development of a 5α-Reductase Inhibitor, Finasteride The Journal of Steroid Biochemistry and Molecular Biology · 1990