TLDR Cyclodextrins improve finasteride's solubility and bioavailability for hair loss treatment.
This document reports on a study investigating the use of cyclodextrins to improve the solubility and bioavailability of finasteride, a drug used to treat hair loss. The study found that the inclusion complexes of finasteride and cyclodextrins had improved solubility and dissolution rates compared to the raw drug. The study suggests that the use of cyclodextrins could enhance the bioavailability of finasteride. The study involved various analyses, including X-ray diffraction, DSC analysis, molecular docking studies, dissolution rate studies, and pharmacokinetic studies in rabbits.
5 citations,
March 2012 in “PubMed” 
100 citations,
April 2010 in “Expert Opinion on Pharmacotherapy” Hair loss in men treated best with early medication or transplant, new treatments researched.
37 citations,
April 2009 in “Bioorganic & Medicinal Chemistry” Finasteride complexes with HPβCD and polymers improve solubility, potentially enhancing hair loss treatment.
211 citations,
November 1990 in “The Journal of Steroid Biochemistry and Molecular Biology” Finasteride effectively treats BPH, but needs more trials to understand potential.
June 2017 in “DOAJ (DOAJ: Directory of Open Access Journals)” Combining finasteride with dimethyl-β-cyclodextrin improves its absorption and bioavailability.
23 citations,
March 2019 in “Environmental Chemistry Letters” Cyclodextrins improve how steroid drugs work and are used in marketed medications and environmental applications.
11 citations,
August 2011 in “Journal of Inclusion Phenomena and Macrocyclic Chemistry” Finasteride's solubility and bioavailability improved by forming solid dispersions and inclusion complexes.
4 citations,
June 2021 in “Powder Technology” Granules improve hair loss treatment by targeting follicles.
2 citations,
July 2022 in “BioMed Research International” Finasteride-loaded nanogels are effective, safe, and improve drug absorption through the skin.
