Experimental, Molecular Docking Investigations and Bioavailability Study on the Inclusion Complexes of Finasteride and Cyclodextrins

    June 2017 in “ Drug Design Development and Therapy ”
    Fatma M. Mady, Usama Farghaly Aly
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    TLDR Cyclodextrins improve finasteride's solubility and bioavailability for hair loss treatment.
    This document reports on a study investigating the use of cyclodextrins to improve the solubility and bioavailability of finasteride, a drug used to treat hair loss. The study found that the inclusion complexes of finasteride and cyclodextrins had improved solubility and dissolution rates compared to the raw drug. The study suggests that the use of cyclodextrins could enhance the bioavailability of finasteride. The study involved various analyses, including X-ray diffraction, DSC analysis, molecular docking studies, dissolution rate studies, and pharmacokinetic studies in rabbits.
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      in Finasteride  71 upvotes 5 days ago
      The user has been using finasteride and minoxidil for 8-9 months without significant improvement in hair loss and is considering switching to dutasteride and topical minoxidil. Another user suggests that dutasteride might be more effective due to its potency and advises patience as hair regrowth can take up to a year.

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      An 18-year-old using topical finasteride for hair loss is experiencing side effects like delayed ejaculation and lower sex drive after three months. They are considering whether to continue with the treatment or adjust it, possibly switching back to minoxidil.

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      in Finasteride  68 upvotes 1 week ago
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