A Rapid, Simple, Liquid Chromatographic-Electrospray Ionization, Ion Trap Mass Spectrometry Method for the Determination of Finasteride in Human Plasma and Its Application to Pharmacokinetic Study

    January 2012 in “ PubMed ”
    Syed Husain Hashemi Mousavi, Farzad Kobarfard, Syed Akhtar Husain, Mohammad Saber-Tehrani, Parviz Aberoomand Azar, Reza Ahmadkhaniha, Amir Mehdizadeh
    TLDR A new method accurately measures finasteride levels in human plasma.
    The study developed a rapid and reliable method using high-performance liquid chromatography and mass spectrometry to measure finasteride levels in human plasma. The method, which involved protein precipitation and a specific column and mobile phase, demonstrated a linear calibration curve from 0.1 to 60 ng/mL and a quantification limit of 0.1 ng/mL. Precision and accuracy were within acceptable ranges. This method was applied to a pharmacokinetic study with 12 healthy volunteers who received a 5 mg oral dose of finasteride.
    Discuss this study in the Community →

    Research cited in this study

    11 / 11 results

    Related Community Posts Join

    6 / 1000+ results

      community CB-03-01: I need help

      in Treatment  7 upvotes 4 years ago
      The user stopped using finasteride and RU58841 and is considering CB-03-01 for androgenic alopecia but is concerned about the cost and effectiveness, especially at a lower dose than in clinical trials. They are also using minoxidil, micro-needling, and nizoral shampoo but are unsure about the correct application method for CB-03-01.

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  41 upvotes 5 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

      community New warning by FDA on topical finasteride

      in Research/Science  194 upvotes 7 months ago
      The FDA warned that topical finasteride can cause serious side effects like sexual dysfunction and brain fog, similar to oral finasteride. Compounded topical formulations pose additional risks due to lack of regulation.

      community I have been battling hair loss for 20 years, feel free to ask me anything

      in Progress Pictures  151 upvotes 2 years ago
      A user's 20 year journey with hair loss and the treatments they have used to manage it, including finasteride, minoxidil, a custom Strut Blend of Dutasteride, Minoxidil, Tretinoin, and Biotin, Nizoral shampoo, multivitamins, Vitamin D, B Complex, Dim, Clomid, exercise, diet, laser helmet, Toppik dark brown, and topical Finasteride. The user also talks about their successful life, lack of desire for children and high sperm count due to Clomid.

    Related Research

    3 / 3 results